Comparative effectiveness and safety of Angio-Seal and StarClose vascular closure devices: a systematic review and meta-analysis

This systematic review and meta-analysis aims to evaluate the effectiveness and safety of Angio-Seal and StarClose vascular closure devices (VCDs) in achieving hemostasis after interventional surgery. Randomized controlled trials (RCTs) and observational studies comparing Angio-Seal and StarClose we...

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Bibliographic Details
Published in:PeerJ (San Francisco, CA) CA), 2024-12, Vol.12, p.e18652, Article e18652
Main Authors: Lai, Kun, Chen, Jingquan, Tan, Qiang, Luo, Lan
Format: Article
Language:English
Subjects:
Angio-seal
Cardiology
Clinical Trials
Drugs and Devices
Hematoma - epidemiology
Hematoma - etiology
Hematoma - prevention & control
Hemostasis
Hemostasis, Surgical - instrumentation
Hemostasis, Surgical - methods
Humans
Meta-analysis
Randomized Controlled Trials as Topic
StarClose
Surgery and Surgical Specialties
Systematic review
Treatment Outcome
Vascular closure devices
Vascular Closure Devices - adverse effects
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Summary:This systematic review and meta-analysis aims to evaluate the effectiveness and safety of Angio-Seal and StarClose vascular closure devices (VCDs) in achieving hemostasis after interventional surgery. Randomized controlled trials (RCTs) and observational studies comparing Angio-Seal and StarClose were identified through systematic searches. Data on vascular closure success rate, complication rates, hematoma formation, pseudoaneurysm, arterial occlusion, and surgical intervention were extracted and pooled using a random effects model. Nine studies met the inclusion criteria, total 5,466 patients. The meta-analysis revealed a slight, statistically significant difference in the success rate of vascular closure in favor of Angio-Seal (risk ratio (RR) 1.05, 95% confidence interval (CI) [1.00-1.09], = 0.03). No significant difference was found in the overall complication rate, hematoma formation, pseudoaneurysm, arterial occlusion, or surgical intervention. Angio-Seal demonstrated a slightly higher success rate in vessel closure compared to StarClose. Both devices had a comparable safety profile with no significant differences in major complications.
ISSN:2167-8359
2167-8359
DOI:10.7717/peerj.18652