CCL3 Promotes Germinal Center B Cells Sampling by Follicular Regulatory T Cells in Murine Lymph Nodes

Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity is poorly understood. We found that CCL3 promo...

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Bibliographic Details
Published in:Frontiers in immunology 2018-09, Vol.9, p.2044-2044
Main Authors: Benet, Zachary L, Marthi, Matangi, Ke, Fang, Wu, Rita, Turner, Jackson S, Gabayre, Jahan B, Ivanitskiy, Michael I, Sethi, Sahil S, Grigorova, Irina L
Format: Article
Language:English
Subjects:
2-photon imaging
CCL3/MIP1-alpha
follicular helper T cells
follicular regulatory T cells (Tfr)
germinal centers
Immunology
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Summary:Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity is poorly understood. We found that CCL3 promotes chemotaxis of Tfr cells . Two-photon imaging revealed that B cells-intrinsic production of CCL3 promotes their probing by follicular regulatory T cells (Tfr) within GCs of murine lymph nodes. Overall this study suggests that CCL3 facilitates direct interactions of foreign antigen-specific GC B cells and their negative regulation with Tfr cells .
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2018.02044