Assessment of Motor Evoked Potentials in Multiple Sclerosis

Transcranial magnetic stimulation (TMS) is a noninvasive technique mainly used for the assessment of corticospinal tract integrity and excitability of the primary motor cortices. Motor evoked potentials (MEPs) play a pivotal role in TMS studies. TMS clinical guidelines, concerning the use and interp...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2023-01, Vol.23 (1), p.497
Main Authors: Šoda, Joško, Pavelin, Sanda, Vujović, Igor, Rogić Vidaković, Maja
Format: Article
Language:English
Subjects:
Biomarkers
Brain research
Congenital diseases
e-field navigation
Evoked potentials
line navigation
Literature reviews
Magnetic resonance imaging
Multiple sclerosis
navigated TMS
Neurophysiology
Practice guidelines (Medicine)
Review
Stimulators
TMS
Transcranial magnetic stimulation
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Summary:Transcranial magnetic stimulation (TMS) is a noninvasive technique mainly used for the assessment of corticospinal tract integrity and excitability of the primary motor cortices. Motor evoked potentials (MEPs) play a pivotal role in TMS studies. TMS clinical guidelines, concerning the use and interpretation of MEPs in diagnosing and monitoring corticospinal tract integrity in people with multiple sclerosis (pwMS), were established almost ten years ago and refer mainly to the use of TMS implementation; this comprises the magnetic stimulator connected to a standard EMG unit, with the positioning of the coil performed by using the external landmarks on the head. The aim of the present work was to conduct a narrative literature review on the MEP assessment and outcome measures in clinical and research settings, assessed by TMS Methodological characteristics of different TMS system implementations (TMS without navigation, line-navigated TMS and e-field-navigated TMS); these were discussed in the context of mapping the corticospinal tract integrity in MS. An MEP assessment of two case reports, by using an e-field-navigated TMS, was presented; the results of the correspondence between the e-field-navigated TMS with MRI, and the EDSS classifications were presented. Practical and technical guiding principles for the improvement of TMS studies in MEP assessment for MS are discussed, suggesting the use of e-field TMS assessment in the sense that it can improve the accuracy of corticospinal tract integrity testing by providing a more objective correspondence of the neurophysiological (e-field-navigated TMS) and clinical (Expanded Disability Status Scale-EDSS) classifications.
ISSN:1424-8220
1424-8220
DOI:10.3390/s23010497