siRNAEfficacyDB: An experimentally supported small interfering RNA efficacy database

• Published in: IET systems biology 2024-12, Vol.18 (6), p.199-207
• Main Authors: Zhang, Yang, Yang, Ting, Yang, Yu, Xu, Dongsheng, Hu, Yucheng, Zhang, Shuo, Luo, Nanchao, Ning, Lin, Ren, Liping
• Format: Article
• Language: English
• Subjects: big data; Databases, Genetic; drugs; Humans; Original Research; RNA; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; Special Section: Computational Applications in High‐throughput Sequencing Data; User-Computer Interface
• ISSN: 1751-8849; 1751-8857; 1751-8857
• DOI: 10.1049/syb2.12102

Small interfering RNA (siRNA) has revolutionised biomedical research and drug development through precise post‐transcriptional gene silencing technology. Despite its immense potential, siRNA therapy still faces technical challenges, such as delivery efficiency, targeting specificity, and molecular stability. To address these challenges and facilitate siRNA drug development, we have developed siRNAEfficacyDB, a comprehensive database that integrates experimentally validated siRNA efficacy data. This database contains 3544 siRNA records, covering 42 target genes and 5 cell lines. It provides detailed information on siRNA sequences, target genes, inhibition efficiencies, experimental techniques, cell lines, siRNA concentrations, and incubation times. siRNAEfficacyDB offers a user‐friendly web interface that makes it easy to query, browse and analyse data, enabling efficient access to siRNA‐related information. In summary, siRNAEfficacyDB provides a useful data foundation for siRNA drug design and optimisation, serving as a valuable resource for advancing computer‐aided siRNA design research and nucleic acid drug development. siRNAEfficacyDB is freely available at https://cellknowledge.com.cn/siRNAEfficacy for non‐commercial use. 1. siRNAEfficacyDB integrates experimentally validated siRNA efficacy data, providing detailed information on 3544 siRNA records. 2. The database features a user‐friendly web interface for easy querying, browsing, and analysis of siRNA‐related information. 3. siRNAEfficacyDB serves as a valuable resource for advancing computer‐aided siRNA design research and nucleic acid drug development.