The Effects of Exercise on Cognitive Recovery after Acquired Brain Injury in Animal Models: A Systematic Review

The objective of the present paper is to review the current status of exercise as a tool to promote cognitive rehabilitation after acquired brain injury (ABI) in animal model-based research. Searches were conducted on the PubMed, Scopus, and psycINFO databases in February 2014. Search strings used w...

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Bibliographic Details
Published in:Journal of neural transplantation & plasticity 2015-01, Vol.2015 (2015), p.368-389-131
Main Authors: Wogensen, Elise, Mogensen, Jesper, Malá, Hana
Format: Article
Language:English
Subjects:
Animals
Brain
Brain Injuries - psychology
Brain Injuries - rehabilitation
Brain research
Cognition
Exercise
Fitness equipment
Humans
Injuries
Intervention
Ischemia
Neurogenesis
Neurotoxicity
Physical Conditioning, Animal
Physical fitness
Recovery of Function
Rehabilitation
Retention
Review
Rodents
Running
Systematic review
Traumatic brain injury
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Summary:The objective of the present paper is to review the current status of exercise as a tool to promote cognitive rehabilitation after acquired brain injury (ABI) in animal model-based research. Searches were conducted on the PubMed, Scopus, and psycINFO databases in February 2014. Search strings used were: exercise (and) animal model (or) rodent (or) rat (and) traumatic brain injury (or) cerebral ischemia (or) brain irradiation. Studies were selected if they were (1) in English, (2) used adult animals subjected to acquired brain injury, (3) used exercise as an intervention tool after inflicted injury, (4) used exercise paradigms demanding movement of all extremities, (5) had exercise intervention effects that could be distinguished from other potential intervention effects, and (6) contained at least one measure of cognitive and/or emotional function. Out of 2308 hits, 22 publications fulfilled the criteria. The studies were examined relative to cognitive effects associated with three themes: exercise type (forced or voluntary), timing of exercise (early or late), and dose-related factors (intensity, duration, etc.). The studies indicate that exercise in many cases can promote cognitive recovery after brain injury. However, the optimal parameters to ensure cognitive rehabilitation efficacy still elude us, due to considerable methodological variations between studies.
ISSN:0792-8483
2090-5904
1687-5443
DOI:10.1155/2015/830871