Functional Localization of Adult-Onset Idiopathic Nesidioblastosis

Nesidioblastosis is a rare pancreatic disorder involving enlarged beta cells throughout the pancreas, causing elevated insulin production. We present the case of a 53-year-old woman with the initial symptom of fasting hypoglycemia. No pancreatic lesions were indicated on computed tomography and magn...

Full description

Saved in:
Bibliographic Details
Published in:Case reports in endocrinology 2022-10, Vol.2022, p.1-4
Main Authors: Hercus, Jess C., Pasha, Pouneh, Al Lawati, Sadiq, Kim, Peter, Mattman, Andre, Webber, Douglas, Thompson, David M.
Format: Article
Language:English
Subjects:
Adults
Case Report
Case reports
Dextrose
Diagnosis
Glucose
Hypoglycemia
Insulin
Localization
Neuroendocrine tumors
Pancreas
Pathology
Patients
Type 2 diabetes
Veins & arteries
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nesidioblastosis is a rare pancreatic disorder involving enlarged beta cells throughout the pancreas, causing elevated insulin production. We present the case of a 53-year-old woman with the initial symptom of fasting hypoglycemia. No pancreatic lesions were indicated on computed tomography and magnetic resonance imaging scans, and an octreotide scan was negative for insulinoma. Selective arterial calcium stimulation (SACST) showed increased insulin production from the stimulation of 3 out of 5 arteries. The SACST results suggested a diagnosis of nesidioblastosis, which was confirmed by histopathology after a subtotal distal pancreatectomy. The patient has normal glucose tolerance after surgery with no further problems of hypoglycemia, indicating that this is a rare case of nesidioblastosis extending only partially through the pancreas.
ISSN:2090-6501
2090-651X
DOI:10.1155/2022/2802975