Pre-diabetes and NAFLD; A study of an Algerian population sample

• Published in: Endocrine and metabolic science 2020-11, Vol.1 (3-4), p.100060, Article 100060
• Main Authors: TAHARBOUCHT, Said, GUERMAZ, Rachida, BROURI, Mansour, CHIBANE, Ahcene
• Format: Article
• Language: English
• Subjects: nonalcoholic fatty liver disease; pre-diabetes; steatosis
• ISSN: 2666-3961; 2666-3961
• DOI: 10.1016/j.endmts.2020.100060

•The link between prediabetes and NAFLD is very little studied in the literature.•Pre-diabetes is more common in NAFLD patients compared to the general population.•This relationship is probably underpinned by a common pathophysiology.•We suggest screening for prediabetes in NAFLDs. Insulin resistance is one of the most important mechanisms involved in the genesis of NAFLD (Non-Alcoholic Fatty Liver Disease), which explains the potential risk of diabetes in this population. The objective of our study was to compare the prevalence of pre-diabetes in people with metabolic steatopathy or NAFLD with that of a general population free from hepatic steatosis. It is a prospective case-control study which focused on non-diabetic patients aged between 30 and 70 years. A clinical and biological assessment was carried out for all patients. Hepatic steatosis was diagnosed by ultrasound. Insulinemia was measured by Fluorescence Enzyme Immunoassay (Tosoh AIA 360) expressed in µU /Ml. The insulin resistance calculation was done using the HOMA formula. Pre diabetes is defined by the American Diabetes Association (ADA) as a fasting blood sugar (8 hours) between 1 and 1.25 g / l. Statistical analyzes were performed using SPSS 21.0 software (IBM). 426 patients aged 48.52 ± 10.13 years (226 women (53.6%)), including 213 with fatty liver disease, were enrolled. The mean fasting blood glucose in NAFLD patients was significantly higher (0.97 ± 0.13 213 Vs 0.92 ± 0.11, p