Electrochemical Cytosensor Based on a Gold Nanostar-Decorated Graphene Oxide Platform for Gastric Cancer Cell Detection

Effectively capturing and sensitively detecting cancer cells are critical to clinical diagnosis and cancer therapy. In this work, we prepared gold nanostar-decorated graphene oxide (GO-AuNSs) nanocomposites using a ultraviolet (UV)-induced strategy, and then modified them with a layer of bio-complex...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2022-04, Vol.22 (7), p.2783
Main Authors: Zhang, Amin, Liu, Qianwen, Huang, Zhicheng, Zhang, Qian, Wang, Ruhao, Cui, Daxiang
Format: Article
Language:English
Subjects:
Biocompatibility
Biosensing Techniques - methods
Biosensors
cancer cell analysis
Diagnosis
DPV
electrochemical cytosensor
Electrochemical Techniques - methods
Electrodes
Folic acid
Gastric cancer
GO-AuNSs@rBSA-FA
Gold
Graphene
Graphite
Humans
Limit of Detection
Microscopy
Nanocomposites
Nanomaterials
Potassium
Prenatal development
Seeds
Serum albumin
Spectrum analysis
Stomach Neoplasms - diagnosis
Surfactants
Voltammetry
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Summary:Effectively capturing and sensitively detecting cancer cells are critical to clinical diagnosis and cancer therapy. In this work, we prepared gold nanostar-decorated graphene oxide (GO-AuNSs) nanocomposites using a ultraviolet (UV)-induced strategy, and then modified them with a layer of bio-complex rBSA-FA (coupled reduced bovine serum albumin with folic acid) to generate GO-AuNSs@rBSA-FA nanocomposites. Herein, the application of GO and AuNSs not only strengthened the conductivity of the sensing platform but also guaranteed nanocomposites with biocompatible performance. Moreover, the adopted rBSA-FA layer could effectively enhance the stability and specificity towards gastric cancer cells (MGC-803). According to a systemic construction procedure, a novel electrochemical cytosensor based on GO-AuNSs@rBSA-FA was fabricated for MGC-803 cell detection. With the assistance of cyclic voltammetry (CV) and differential pulse voltammetry (DPV), the cytosensor reached a detection limit of 100 cell/mL in a wide linear range of 3 × 10 ~7 × 10 cell/mL towards MGC-803 cells. The good electrochemical characteristics for the cancer cell analysis indicate a promising prospect of this electrochemical cytosensor in clinical cancer diagnosis.
ISSN:1424-8220
1424-8220
DOI:10.3390/s22072783