Stem Cells and Tissue Niche: Two Faces of the Same Coin of Muscle Regeneration

Capacity of adult muscle to regenerate in response to injury stimuli represents an important homeostatic process. Regeneration is a highly coordinated program that partially recapitulates the embryonic developmental program. However, muscle regeneration is severely compromised in several pathologica...

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Bibliographic Details
Published in:European journal of translational myology 2016-11, Vol.26 (4), p.6125-6125
Main Authors: Scicchitano, Bianca Maria, Sica, Gigliola, Musarò, Antonio
Format: Article
Language:English
Subjects:
IGF-1
Muscle pathologies
Muscle regeneration
Myology Made in Italy
Satellite cells
Tissue niche
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Summary:Capacity of adult muscle to regenerate in response to injury stimuli represents an important homeostatic process. Regeneration is a highly coordinated program that partially recapitulates the embryonic developmental program. However, muscle regeneration is severely compromised in several pathological conditions. It is likely that the restricted tissue repair program under pathological conditions is due to either progressive loss of stem cell populations or to missing signals that limit the damaged tissues to efficiently activate a regenerative program. It is therefore plausible that loss of control over these cell fates might lead to a pathological cell transdifferentiation, limiting the ability of a pathological muscle to sustain an efficient regenerative process. The critical role of microenvironment on stem cells activity and muscle regeneration is discussed.
ISSN:2037-7452
2037-7460
DOI:10.4081/ejtm.2016.6125