Tissue Distribution of Oleocanthal and Its Metabolites after Oral Ingestion in Rats

Claims for the potential health benefits of oleocanthal (OLC), a dietary phenolic compound found in olive oil, are based mainly on in vitro studies. Little is known about the tissue availability of OLC, which is rapidly metabolized after ingestion. In this study, the distribution of OLC and its meta...

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Bibliographic Details
Published in:Antioxidants 2021-04, Vol.10 (5), p.688
Main Authors: López-Yerena, Anallely, Vallverdú-Queralt, Anna, Jáuregui, Olga, Garcia-Sala, Xavier, Lamuela-Raventós, Rosa M, Escribano-Ferrer, Elvira
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
bioaccumulation
Bioavailability
Diet
extra virgin olive oil
Kidneys
LC-ESI-LTQ-Orbitrap
Liver
Metabolism
Metabolites
Olive oil
Particle size
Phenolic compounds
Physiology
Plasma
polyphenols
Small intestine
Spleen
Stomach
Thyroid
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Summary:Claims for the potential health benefits of oleocanthal (OLC), a dietary phenolic compound found in olive oil, are based mainly on in vitro studies. Little is known about the tissue availability of OLC, which is rapidly metabolized after ingestion. In this study, the distribution of OLC and its metabolites in rat plasma and tissues (stomach, intestine, liver, kidney, spleen, lungs, heart, brain, thyroid and skin) at 1, 2 and 4.5 h after the acute intake of a refined olive oil containing 0.3 mg/mL of OLC was examined by LC-ESI-LTQ-Orbitrap-MS. OLC was only detected in the stomach and intestine samples. Moreover, at 2 and 4.5 h, the concentration in the stomach decreased by 36% and 74%, respectively, and in the intestine by 16% and 33%, respectively. Ten OLC metabolites arising from phase I and phase II reactions were identified. The metabolites were widely distributed in rat tissues, and the most important metabolizing organs were the small intestine and liver. The two main circulating metabolites were the conjugates OLC + OH + CH and OLC + H O + glucuronic acid, which may significantly contribute to the beneficial health effects associated with the regular consumption of extra virgin olive oil. However, more studies are necessary to determine the concentrations and molecular structures of OLC metabolites in human plasma and tissues when consumed with the presence of other phenolic compunds present in EVOO.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox10050688