Is Brain-Derived Neurotrophic Factor a Metabolic Hormone in Peripheral Tissues?

Brain-derived neurotrophic factor (BDNF) is an important growth factor in the central nervous system. In addition to its well-known activities in promoting neuronal survival, neuron differentiation, and synaptic plasticity, neuronal BDNF also regulates energy homeostasis by modulating the hypothalam...

Full description

Saved in:
Bibliographic Details
Published in:Biology (Basel, Switzerland) Switzerland), 2022-07, Vol.11 (7), p.1063
Main Authors: Iu, Elsie Chit Yu, Chan, Chi Bun
Format: Article
Language:English
Subjects:
Adipose tissue
Autocrine signalling
BDNF
Bipolar disorder
Brain-derived neurotrophic factor
Central nervous system
Energy balance
Homeostasis
Hypothalamus
Kinases
metabolism
Mitochondria
Paracrine signalling
peripheral tissues
Review
Rodents
Skeletal muscle
Synaptic plasticity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Brain-derived neurotrophic factor (BDNF) is an important growth factor in the central nervous system. In addition to its well-known activities in promoting neuronal survival, neuron differentiation, and synaptic plasticity, neuronal BDNF also regulates energy homeostasis by modulating the hypothalamus’s hormonal signals. In the past decades, several peripheral tissues, including liver, skeletal muscle, and white adipose tissue, were demonstrated as the active sources of BDNF synthesis in response to different metabolic challenges. Nevertheless, the functions of BDNF in these tissues remain obscure. With the use of tissue-specific Bdnf knockout animals and the availability of non-peptidyl BDNF mimetic, increasing evidence has reported that peripheral tissues-derived BDNF might play a significant role in maintaining systemic metabolism, possibly through the regulation of mitochondrial dynamics in the various tissues. This article reviews the autocrine/paracrine/endocrine functions of BDNF in non-neuronal tissues and discusses the unresolved questions about BDNF’s function.
ISSN:2079-7737
2079-7737
DOI:10.3390/biology11071063