Undervaccination with diphtheria, tetanus, and pertussis vaccine: National trends and association with pertussis risk in young children

The high coverage for ≥3 pertussis vaccine doses among Taiwanese children might not imply timely vaccination. Recently, resurgence of pertussis and challenges with availability of DTaP-IPV-Hib prompted this study. In the 1996-2012 national birth cohort, we calculated the prevalence and days of under...

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Bibliographic Details
Published in:Human vaccines & immunotherapeutics 2017-04, Vol.13 (4), p.757-761
Main Authors: Huang, Wan-Ting, Lin, Hui-Chen, Yang, Chin-Hui
Format: Article
Language:English
Subjects:
Child, Preschool
Diphtheria-Tetanus-acellular Pertussis Vaccines - administration & dosage
Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology
Female
Humans
Immunization - utilization
immunization schedules
Infant
Infant, Newborn
Male
pertussis
Retrospective Studies
Risk Factors
Short Reports
taiwan
Taiwan - epidemiology
timeliness
undervaccination
vaccine shortage
Whooping Cough - epidemiology
Whooping Cough - prevention & control
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Summary:The high coverage for ≥3 pertussis vaccine doses among Taiwanese children might not imply timely vaccination. Recently, resurgence of pertussis and challenges with availability of DTaP-IPV-Hib prompted this study. In the 1996-2012 national birth cohort, we calculated the prevalence and days of undervaccination against pertussis by age 36 months. We also compared the odds of undervaccination in each laboratory-confirmed pertussis patient at ages 3-35 months with sex-, residence-, and age-matched controls from the general population, using conditional logistic regression. The prevalence of undervaccination was 60.6% (median 16 days) and decreasing (p < 0.0001). Among 145 cases and 2,900 controls, 58 (40.0%) and 721 (24.9%) were undervaccinated (OR 2.28, 95% CI 1.57-3.31). The attributable risk percent was 22.5% (95% CI 14.5-27.9). Undervaccination was decreasing. Approximately up to one-fifth pertussis cases in children aged 3-35 months could have been prevented with on-time vaccination.
ISSN:2164-5515
2164-554X
DOI:10.1080/21645515.2016.1249552