Culture-negative endocarditis with neurologic presentations and dramatic response to heparin: a case report

Blood culture-negative endocarditis (BCNE) is diagnosed in 2-7% of patients with infective endocarditis (IE) and recent antibiotic use is a known risk factor. Altered mental status may be a presenting symptom. Besides empiric antibiotics, intravenous anticoagulation using heparin may have a role in...

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Bibliographic Details
Published in:BMC infectious diseases 2020-07, Vol.20 (1), p.1-476, Article 476
Main Authors: Sheibani, Hossein, Salari, Mohammad, Azmoodeh, Elham, Kheirieh, Amirhessam, Chaghazardi, Sara
Format: Article
Language:English
Subjects:
Abnormalities
Antibiotics
Antibodies
Anticoagulants
Aphasia
Bacterial endocarditis
Blood
Blood culture
Blood platelets
Blood pressure
Brain damage
Case Report
Case reports
Cerebellum
Collagen
Diagnosis
Echocardiography
EKG
Electrocardiography
Embolization
Endocarditis
Fever
Gait
Heart valves
Heparin
Hepatitis
Infectious diseases
Intracranial embolism
Intravenous administration
Laboratories
Lesions
Magnetic resonance imaging
Meropenem
Mitral valve
Patients
Risk analysis
Risk factors
Signs and symptoms
Tricuspid valve
Ventricle
Ventricles (cerebral)
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Summary:Blood culture-negative endocarditis (BCNE) is diagnosed in 2-7% of patients with infective endocarditis (IE) and recent antibiotic use is a known risk factor. Altered mental status may be a presenting symptom. Besides empiric antibiotics, intravenous anticoagulation using heparin may have a role in the management of such patients. BCNE should be considered in patients with fever and neurologic manifestations. TTE should be performed to detect valvular abnormalities. Intravenous heparin could be used in such patients when TTE demonstrate valvular vegetations.
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-020-05206-0