Neuroprotective and Nerve Regenerative Approaches for Treatment of Erectile Dysfunction after Cavernous Nerve Injury

Erectile dysfunction (ED) is a significant cause of reduced quality of life in men and their partners. Cavernous nerve injury (CNI) during pelvic surgery results in ED in greater than 50% of patients, regardless of additional patient factors. ED related to CNI is difficult to treat and typically poo...

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Bibliographic Details
Published in:International journal of molecular sciences 2017-08, Vol.18 (8), p.1794
Main Authors: Campbell, Jeffrey D, Burnett, Arthur L
Format: Article
Language:English
Subjects:
Androgens
Animals
cavernous nerve injury
Construction
Drug therapy
Erectile dysfunction
Erectile Dysfunction - etiology
Erectile Dysfunction - physiopathology
Erectile Dysfunction - therapy
Gene therapy
Humans
Injury prevention
Male
Nerve Regeneration - physiology
Nervous system
Neuroprotection
Patients
Pelvis
Penis - innervation
Penis - physiopathology
Peripheral Nerve Injuries - complications
Peripheral Nerve Injuries - physiopathology
Precision medicine
Precision Medicine - methods
Quality of Life
regenerative medicine
Review
Salvage
Sexual disorders
Stem cells
Therapeutic applications
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Summary:Erectile dysfunction (ED) is a significant cause of reduced quality of life in men and their partners. Cavernous nerve injury (CNI) during pelvic surgery results in ED in greater than 50% of patients, regardless of additional patient factors. ED related to CNI is difficult to treat and typically poorly responsive to first- and second-line therapeutic options. Recently, a significant amount of research has been devoted to exploring neuroprotective and neuroregenerative approaches to salvage erectile function in patients with CNI. In addition, therapeutic options such as neuregulins, immunophilin ligands, gene therapy, stem cell therapy and novel surgical strategies, have shown benefit in pre-clinical, and limited clinical studies. In the era of personalized medicine, these new therapeutic technologies will be the future of ED treatment and are described in this review.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms18081794