Distributed implantation of a flexible microelectrode array for neural recording

Flexible multichannel electrode arrays (fMEAs) with multiple filaments can be flexibly implanted in various patterns. It is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording demands. This study proposed a strategy for reducing t...

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Bibliographic Details
Published in:Microsystems & nanoengineering 2022-05, Vol.8 (1), p.50-50, Article 50
Main Authors: Wei, Chunrong, Wang, Yang, Pei, Weihua, Han, Xinyong, Lin, Longnian, Liu, Zhiduo, Ming, Gege, Chen, Ruru, Wu, Pingping, Yang, Xiaowei, Zheng, Li, Wang, Yijun
Format: Article
Language:English
Subjects:
639/166/987
639/925/929
Aluminum
Arrays
Brain
Electrodes
Engineering
Filaments
Gold
Implantation
Methods
Microelectrodes
Microelectromechanical systems
Packaging
Polyethylene glycol
Protective coatings
Recording
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Description
Summary:Flexible multichannel electrode arrays (fMEAs) with multiple filaments can be flexibly implanted in various patterns. It is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording demands. This study proposed a strategy for reducing the microelectrode volume with integrated packaging. An implantation system was developed specifically for semiautomatic distributed implantation. The feasibility and convenience of the fMEA and implantation platform were verified in rodents. The acute and chronic recording results provied the effectiveness of the packaging and implantation methods. These methods could provide a novel strategy for developing fMEAs with more filaments and recording sites to measure functional interactions across multiple brain regions.
ISSN:2055-7434
2096-1030
2055-7434
DOI:10.1038/s41378-022-00366-2