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Is titanium alloy Ti‐6Al‐4 V cytotoxic to gingival fibroblasts—A systematic review
Objectives Grade V titanium alloy (Ti‐6Al‐4 V) is a well‐recognized metallic biomaterial for medical implants. There has been some controversy regarding the use of this alloy in medical devices in relation to the toxicity of vanadium. In Dentistry, Ti‐6Al‐4 V remains prevalent. This systematic revie...
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| Published in: | Clinical and experimental dental research 2021-12, Vol.7 (6), p.1037-1044 |
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| container_end_page | 1044 |
| container_issue | 6 |
| container_start_page | 1037 |
| container_title | Clinical and experimental dental research |
| container_volume | 7 |
| creator | Willis, Jonathan Li, Siwei Crean, St John Barrak, Fadi N. |
| description | Objectives
Grade V titanium alloy (Ti‐6Al‐4 V) is a well‐recognized metallic biomaterial for medical implants. There has been some controversy regarding the use of this alloy in medical devices in relation to the toxicity of vanadium. In Dentistry, Ti‐6Al‐4 V remains prevalent. This systematic review aims to evaluate the effects of Ti‐6Al‐4 V on cells relevant to oral environments such as gingival fibroblasts.
Materials and methods
A literature search was undertaken for relevant English language publications in the following databases: Dental and Oral Science, Medline and Web of Science. The electronic search was supplemented with a search of references.
Results
After application of inclusion and exclusion criteria. A total of eight papers are included in this review. These papers were all in vitro studies and were categorized into whole implant, discs, or implant particles based on the type of test materials used in the studies.
Conclusion
Based on the analyses of the eight included studies in this review, if Ti‐6Al‐4 V as a material is unchallenged, i.e., as a whole implant in pH neutral environments, there appears to be little effect on fibroblasts. If Ti‐6Al‐4 V is challenged through corrosion or wear (particle release), the subsequent release of vanadium and aluminium particles has an increased cytotoxic effect in vitro in comparison to commercially pure titanium, hence concerns should be raised in the clinical setting. |
| doi_str_mv | 10.1002/cre2.444 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_f636e48d41ac48a2a35b4d3c121c0723</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_f636e48d41ac48a2a35b4d3c121c0723</doaj_id><sourcerecordid>2605144476</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5044-20f26f1a7ff75d4a68f25ffa4bdde6fbfd3cf861a4549a9095abed1b448e94713</originalsourceid><addsrcrecordid>eNp1kd9qFDEUhwdRbKkFn0AGvPFmav6cyWRuhGWpdqEgSBW8CmcyyZpldlKT7Na56yN40QfwWXyUPolZt5b2wpsknHx85xx-RfGSkhNKCHurg2EnAPCkOGSkbirg0Dx98D4ojmNcEUKoIIS3_HlxwIFQ2RB-WHxdxDK5hKPbrEscBj-VF-72-qeYDfmE37--lHpKPvkfTpfJl0s3Lt0Wh9K6LvhuwJji7fXNrIxTTGaNKWPBbJ25elE8szhEc3x3HxWf359ezM-q848fFvPZeaVrAlAxYpmwFBtrm7oHFNKy2lqEru-NsJ3tubZSUIQaWmxJW2NnetoBSNNCQ_lRsdh7e48rdRncGsOkPDr1t-DDUmHIYw1GWcGFAdkDRQ0SGfK6g-ynjGrSMJ5d7_auy023Nr02Ywo4PJI-_hndN7X0WyUFl0zKLHh9Jwj--8bEpFZ-E8a8v2KC1DTH1IhMvdlTOvgYg7H3HShRu0zVLlOV4Yy-ejjRPfgvwQxUe-DKDWb6r0jNP52ynfAP-CWu6A</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2605144476</pqid></control><display><type>article</type><title>Is titanium alloy Ti‐6Al‐4 V cytotoxic to gingival fibroblasts—A systematic review</title><source>Wiley Online Library Open Access</source><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Willis, Jonathan ; Li, Siwei ; Crean, St John ; Barrak, Fadi N.</creator><creatorcontrib>Willis, Jonathan ; Li, Siwei ; Crean, St John ; Barrak, Fadi N.</creatorcontrib><description>Objectives
Grade V titanium alloy (Ti‐6Al‐4 V) is a well‐recognized metallic biomaterial for medical implants. There has been some controversy regarding the use of this alloy in medical devices in relation to the toxicity of vanadium. In Dentistry, Ti‐6Al‐4 V remains prevalent. This systematic review aims to evaluate the effects of Ti‐6Al‐4 V on cells relevant to oral environments such as gingival fibroblasts.
Materials and methods
A literature search was undertaken for relevant English language publications in the following databases: Dental and Oral Science, Medline and Web of Science. The electronic search was supplemented with a search of references.
Results
After application of inclusion and exclusion criteria. A total of eight papers are included in this review. These papers were all in vitro studies and were categorized into whole implant, discs, or implant particles based on the type of test materials used in the studies.
Conclusion
Based on the analyses of the eight included studies in this review, if Ti‐6Al‐4 V as a material is unchallenged, i.e., as a whole implant in pH neutral environments, there appears to be little effect on fibroblasts. If Ti‐6Al‐4 V is challenged through corrosion or wear (particle release), the subsequent release of vanadium and aluminium particles has an increased cytotoxic effect in vitro in comparison to commercially pure titanium, hence concerns should be raised in the clinical setting.</description><identifier>ISSN: 2057-4347</identifier><identifier>EISSN: 2057-4347</identifier><identifier>DOI: 10.1002/cre2.444</identifier><identifier>PMID: 34018703</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Alloys ; Biopsy ; Cell culture ; Cytotoxicity ; Dental implants ; Dental Implants - adverse effects ; Dentistry ; Fibroblasts ; Fluorides ; Fractures ; implant ; Materials Testing ; Medical technology ; Orthopedics ; peri‐implantitis ; Review ; Stainless steel ; Systematic review ; Titanium - toxicity ; Titanium alloys ; Ti‐6Al‐4 V alloy</subject><ispartof>Clinical and experimental dental research, 2021-12, Vol.7 (6), p.1037-1044</ispartof><rights>2021 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2021 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5044-20f26f1a7ff75d4a68f25ffa4bdde6fbfd3cf861a4549a9095abed1b448e94713</citedby><cites>FETCH-LOGICAL-c5044-20f26f1a7ff75d4a68f25ffa4bdde6fbfd3cf861a4549a9095abed1b448e94713</cites><orcidid>0000-0002-1042-0012</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2605144476/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2605144476?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,11541,25731,27901,27902,36989,44566,46027,46451,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34018703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Willis, Jonathan</creatorcontrib><creatorcontrib>Li, Siwei</creatorcontrib><creatorcontrib>Crean, St John</creatorcontrib><creatorcontrib>Barrak, Fadi N.</creatorcontrib><title>Is titanium alloy Ti‐6Al‐4 V cytotoxic to gingival fibroblasts—A systematic review</title><title>Clinical and experimental dental research</title><addtitle>Clin Exp Dent Res</addtitle><description>Objectives
Grade V titanium alloy (Ti‐6Al‐4 V) is a well‐recognized metallic biomaterial for medical implants. There has been some controversy regarding the use of this alloy in medical devices in relation to the toxicity of vanadium. In Dentistry, Ti‐6Al‐4 V remains prevalent. This systematic review aims to evaluate the effects of Ti‐6Al‐4 V on cells relevant to oral environments such as gingival fibroblasts.
Materials and methods
A literature search was undertaken for relevant English language publications in the following databases: Dental and Oral Science, Medline and Web of Science. The electronic search was supplemented with a search of references.
Results
After application of inclusion and exclusion criteria. A total of eight papers are included in this review. These papers were all in vitro studies and were categorized into whole implant, discs, or implant particles based on the type of test materials used in the studies.
Conclusion
Based on the analyses of the eight included studies in this review, if Ti‐6Al‐4 V as a material is unchallenged, i.e., as a whole implant in pH neutral environments, there appears to be little effect on fibroblasts. If Ti‐6Al‐4 V is challenged through corrosion or wear (particle release), the subsequent release of vanadium and aluminium particles has an increased cytotoxic effect in vitro in comparison to commercially pure titanium, hence concerns should be raised in the clinical setting.</description><subject>Alloys</subject><subject>Biopsy</subject><subject>Cell culture</subject><subject>Cytotoxicity</subject><subject>Dental implants</subject><subject>Dental Implants - adverse effects</subject><subject>Dentistry</subject><subject>Fibroblasts</subject><subject>Fluorides</subject><subject>Fractures</subject><subject>implant</subject><subject>Materials Testing</subject><subject>Medical technology</subject><subject>Orthopedics</subject><subject>peri‐implantitis</subject><subject>Review</subject><subject>Stainless steel</subject><subject>Systematic review</subject><subject>Titanium - toxicity</subject><subject>Titanium alloys</subject><subject>Ti‐6Al‐4 V alloy</subject><issn>2057-4347</issn><issn>2057-4347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp1kd9qFDEUhwdRbKkFn0AGvPFmav6cyWRuhGWpdqEgSBW8CmcyyZpldlKT7Na56yN40QfwWXyUPolZt5b2wpsknHx85xx-RfGSkhNKCHurg2EnAPCkOGSkbirg0Dx98D4ojmNcEUKoIIS3_HlxwIFQ2RB-WHxdxDK5hKPbrEscBj-VF-72-qeYDfmE37--lHpKPvkfTpfJl0s3Lt0Wh9K6LvhuwJji7fXNrIxTTGaNKWPBbJ25elE8szhEc3x3HxWf359ezM-q848fFvPZeaVrAlAxYpmwFBtrm7oHFNKy2lqEru-NsJ3tubZSUIQaWmxJW2NnetoBSNNCQ_lRsdh7e48rdRncGsOkPDr1t-DDUmHIYw1GWcGFAdkDRQ0SGfK6g-ynjGrSMJ5d7_auy023Nr02Ywo4PJI-_hndN7X0WyUFl0zKLHh9Jwj--8bEpFZ-E8a8v2KC1DTH1IhMvdlTOvgYg7H3HShRu0zVLlOV4Yy-ejjRPfgvwQxUe-DKDWb6r0jNP52ynfAP-CWu6A</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Willis, Jonathan</creator><creator>Li, Siwei</creator><creator>Crean, St John</creator><creator>Barrak, Fadi N.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><general>Wiley</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1042-0012</orcidid></search><sort><creationdate>202112</creationdate><title>Is titanium alloy Ti‐6Al‐4 V cytotoxic to gingival fibroblasts—A systematic review</title><author>Willis, Jonathan ; Li, Siwei ; Crean, St John ; Barrak, Fadi N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5044-20f26f1a7ff75d4a68f25ffa4bdde6fbfd3cf861a4549a9095abed1b448e94713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alloys</topic><topic>Biopsy</topic><topic>Cell culture</topic><topic>Cytotoxicity</topic><topic>Dental implants</topic><topic>Dental Implants - adverse effects</topic><topic>Dentistry</topic><topic>Fibroblasts</topic><topic>Fluorides</topic><topic>Fractures</topic><topic>implant</topic><topic>Materials Testing</topic><topic>Medical technology</topic><topic>Orthopedics</topic><topic>peri‐implantitis</topic><topic>Review</topic><topic>Stainless steel</topic><topic>Systematic review</topic><topic>Titanium - toxicity</topic><topic>Titanium alloys</topic><topic>Ti‐6Al‐4 V alloy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Willis, Jonathan</creatorcontrib><creatorcontrib>Li, Siwei</creatorcontrib><creatorcontrib>Crean, St John</creatorcontrib><creatorcontrib>Barrak, Fadi N.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Clinical and experimental dental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Willis, Jonathan</au><au>Li, Siwei</au><au>Crean, St John</au><au>Barrak, Fadi N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is titanium alloy Ti‐6Al‐4 V cytotoxic to gingival fibroblasts—A systematic review</atitle><jtitle>Clinical and experimental dental research</jtitle><addtitle>Clin Exp Dent Res</addtitle><date>2021-12</date><risdate>2021</risdate><volume>7</volume><issue>6</issue><spage>1037</spage><epage>1044</epage><pages>1037-1044</pages><issn>2057-4347</issn><eissn>2057-4347</eissn><abstract>Objectives
Grade V titanium alloy (Ti‐6Al‐4 V) is a well‐recognized metallic biomaterial for medical implants. There has been some controversy regarding the use of this alloy in medical devices in relation to the toxicity of vanadium. In Dentistry, Ti‐6Al‐4 V remains prevalent. This systematic review aims to evaluate the effects of Ti‐6Al‐4 V on cells relevant to oral environments such as gingival fibroblasts.
Materials and methods
A literature search was undertaken for relevant English language publications in the following databases: Dental and Oral Science, Medline and Web of Science. The electronic search was supplemented with a search of references.
Results
After application of inclusion and exclusion criteria. A total of eight papers are included in this review. These papers were all in vitro studies and were categorized into whole implant, discs, or implant particles based on the type of test materials used in the studies.
Conclusion
Based on the analyses of the eight included studies in this review, if Ti‐6Al‐4 V as a material is unchallenged, i.e., as a whole implant in pH neutral environments, there appears to be little effect on fibroblasts. If Ti‐6Al‐4 V is challenged through corrosion or wear (particle release), the subsequent release of vanadium and aluminium particles has an increased cytotoxic effect in vitro in comparison to commercially pure titanium, hence concerns should be raised in the clinical setting.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>34018703</pmid><doi>10.1002/cre2.444</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1042-0012</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical and experimental dental research, 2021-12, Vol.7 (6), p.1037-1044 |
| issn | 2057-4347 2057-4347 |
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| source | Wiley Online Library Open Access; Publicly Available Content Database; PubMed Central |
| subjects | Alloys Biopsy Cell culture Cytotoxicity Dental implants Dental Implants - adverse effects Dentistry Fibroblasts Fluorides Fractures implant Materials Testing Medical technology Orthopedics peri‐implantitis Review Stainless steel Systematic review Titanium - toxicity Titanium alloys Ti‐6Al‐4 V alloy |
| title | Is titanium alloy Ti‐6Al‐4 V cytotoxic to gingival fibroblasts—A systematic review |
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