Effects of vitamin D and omega-3 fatty acids co-supplementation on inflammatory biomarkers, tumor marker CEA, and nutritional status in patients with colorectal cancer: a study protocol for a double blind randomized controlled trial

Much evidence is available demonstrating that both vitamin D and omega-3 fatty acids block the development and progression of colonic carcinogenesis. The results of animal studies have shown that the consumption of omega-3 fatty acids can decrease inflammatory biomarkers, enhance the efficacy of che...

Full description

Saved in:
Bibliographic Details
Published in:Current controlled trials in cardiovascular medicine 2019-12, Vol.20 (1), p.682-7, Article 682
Main Authors: Haidari, Fatemeh, Abiri, Behnaz, Iravani, Masood, Razavi, Seyed-Mohsen, Sarbakhsh, Parvin, Ahmadi-Angali, Kambiz, Vafa, Mohammadreza
Format: Article
Language:English
Subjects:
Adjuvant chemotherapy
Analysis
Angiogenesis
Apoptosis
Biological markers
Biomarkers
Body mass index
Cancer patients
Cancer research
Cancer therapies
Cancer treatment
Carcinoembryonic antigen
Carcinogenesis
Chemotherapy
Clinical trials
Colorectal cancer
Dietary supplements
Double-blind studies
Fatty acids
Fish oils
Inflammatory biomarkers
Medical research
Metastasis
Mortality
Nutritional status
Omega-3 fatty acids
Study Protocol
Tumor marker CEA
Tumors
Vitamin D
Vitamins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Much evidence is available demonstrating that both vitamin D and omega-3 fatty acids block the development and progression of colonic carcinogenesis. The results of animal studies have shown that the consumption of omega-3 fatty acids can decrease inflammatory biomarkers, enhance the efficacy of chemotherapy, and decrease the side effects of chemotherapy or cancer. Also, observational studies propose that higher levels of 25(OH)D are related to improved survival of colorectal cancer patients. This study will aim to evaluate the effects of vitamin D and omega-3 fatty acids co-supplementation on inflammatory biomarkers, tumor marker CEA, and nutritional status in colorectal cancer patients. We will carry out an 8-week double-blind randomized, placebo-controlled clinical trial to evaluate the effects of vitamin D and omega-3 fatty acids co-supplementation on inflammatory biomarkers, tumor marker CEA, and nutritional status in patients with stage ӀӀ or ӀӀӀ colorectal cancer undergoing chemotherapy. Because of the important effects of vitamin D and omega-3 fatty acids on molecular pathways involved in cancer development and progression, it seems that both vitamin D and omega-3 fatty acids may provide a new adjuvant therapy by decreasing inflammatory biomarkers and resistance to cancer treatment in patients with colorectal cancer. Iranian Registry of Clinical Trials IRCT20180306038979N1. Registered on 16 March 2018.
ISSN:1745-6215
1745-6215
DOI:10.1186/s13063-019-3719-3