The microRNA-200 family regulates epithelial to mesenchymal transition

Epithelial-mesenchymal transition (EMT) is implicated in metastasis initiation and has recently been shown to be regulated by the miRNA-200 family and miR-205. Expression of these miRNAs was lost in invasive breast cancer cell lines displaying mesenchymal-like morphology suggesting these microRNAs m...

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Bibliographic Details
Published in:TheScientificWorld 2008-09, Vol.8, p.901-904
Main Authors: Paterson, Emily L, Kolesnikoff, Natasha, Gregory, Philip A, Bert, Andrew G, Khew-Goodall, Yeesim, Goodall, Gregory J
Format: Article
Language:English
Subjects:
Animals
Cell Line
Directions in Science
Dogs
Epithelium - physiology
Homeodomain Proteins - physiology
Humans
Mesoderm - physiology
MicroRNAs - physiology
Neoplasm Metastasis - physiopathology
Neoplasms - etiology
Nerve Tissue Proteins - physiology
RNA-Binding Proteins - physiology
Transcription Factors - physiology
Zinc Finger E-box-Binding Homeobox 1
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Description
Summary:Epithelial-mesenchymal transition (EMT) is implicated in metastasis initiation and has recently been shown to be regulated by the miRNA-200 family and miR-205. Expression of these miRNAs was lost in invasive breast cancer cell lines displaying mesenchymal-like morphology suggesting these microRNAs may play a role in cancer metastasis.
ISSN:1537-744X
2356-6140
1537-744X
DOI:10.1100/tsw.2008.115