Cumulative dietary risk characterisation of pesticides that have acute effects on the nervous system

• Published in: EFSA journal 2020-04, Vol.18 (4), p.e06087-n/a
• Main Authors: Craig, Peter S, Dujardin, Bruno, Hart, Andy, Hernández‐Jerez, Antonio F, Hougaard Bennekou, Susanne, Kneuer, Carsten, Ossendorp, Bernadette, Pedersen, Ragnor, Wolterink, Gerrit, Mohimont, Luc
• Format: Article
• Language: English
• Subjects: Acetylcholinesterase; Acute effects; cumulative risk assessment; Diet; Erythrocytes; Estimates; expert knowledge elicitation; Exposure; Metabolites; Monitoring; Nervous system; Neuropathology; Pesticide residues; Pesticides; Populations; probabilistic modelling; Public health; Risk assessment; Risk management; Scientific Report; Software; Software development tools; Toddlers; Uncertainty analysis
• ISSN: 1831-4732; 1831-4732; 2314-9396
• DOI: 10.2903/j.efsa.2020.6087

A retrospective acute cumulative risk assessment of dietary exposure to pesticide residues, supported by an uncertainty analysis based on expert knowledge elicitation, was conducted for two effects on the nervous system: brain and/or erythrocyte acetylcholinesterase inhibition, and functional alterations of the motor division. The pesticides considered in this assessment were identified and characterised in the scientific report on the establishment of cumulative assessment groups of pesticides for their effects on the nervous system. Cumulative exposure assessments were conducted through probabilistic modelling by EFSA and the Dutch National Institute for Public Health and the Environment (RIVM) using two different software tools and reported separately. These exposure assessments used monitoring data collected by Member States under their official pesticide monitoring programmes in 2014, 2015 and 2016 and individual consumption data from 10 populations of consumers from different countries and different age groups. This report completes the characterisation of cumulative risk, taking account of the available data and the uncertainties involved. For each of the 10 populations, it is concluded with varying degrees of certainty that cumulative exposure to pesticides that have the acute effects on the nervous system mentioned above does not exceed the threshold for regulatory consideration established by risk managers. This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2020.EN-1836/full http://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2020.EN-1835/full This publication is linked to the following EFSA Journal articles: http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2020.6088/full