A common trajectory of gut microbiome development during the first month in healthy neonates with limited inter-individual environmental variations

The early development of the gut microbiome is governed by multiple factors and has significantly long-term effects on later-in-life health. To minimize inter-individual variations in the environment, we determined developmental trajectories of the gut microbiome in 28 healthy neonates during their...

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Bibliographic Details
Published in:Scientific reports 2024-02, Vol.14 (1), p.3264-3264, Article 3264
Main Authors: Wang, Xing-An, Li, Ju-Pi, Lee, Maw-Sheng, Yang, Shun-Fa, Chang, Yi-Sheng, Chen, Ling, Li, Chang-Wei, Chao, Yu-Hua
Format: Article
Language:English
Subjects:
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692/308
692/4020
Anti-Bacterial Agents - therapeutic use
Digestive system
Environmental factors
Feces
Feces - microbiology
Female
Gastrointestinal Microbiome
Humanities and Social Sciences
Humans
Infant, Newborn
Intestinal microflora
Long-term effects
Meconium
Meconium - microbiology
Microbiomes
Microbiota
multidisciplinary
Neonates
Phototherapy
RNA, Ribosomal, 16S - genetics
rRNA 16S
Science
Science (multidisciplinary)
Variation
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Summary:The early development of the gut microbiome is governed by multiple factors and has significantly long-term effects on later-in-life health. To minimize inter-individual variations in the environment, we determined developmental trajectories of the gut microbiome in 28 healthy neonates during their stay at a postpartum center. Stool samples were collected at three time points: the first-pass meconium within 24 h of life, and at 7 and 28 days of age. Illumina sequencing of the V3–V4 region of 16S rRNA was used to investigate microbiota profiles. We found that there was a distinct microbiota structure at each time point, with a significant shift during the first week. Proteobacteria was most abundant in the first-pass meconium; Firmicutes and Actinobacteria increased with age and were substituted as the major components. Except for a short-term influence of different delivery modes on the microbiota composition, early microbiome development was not remarkably affected by gravidity, maternal intrapartum antibiotic treatment, premature rupture of membranes, or postnatal phototherapy. Hence, our data showed a similar developmental trajectory of the gut microbiome during the first month in healthy neonates when limited in environmental variations. Environmental factors external to the host were crucial in the early microbiome development.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-53949-6