Diagnostic value of 18F-FDG PET/CT versus contrast-enhanced MRI for venous tumour thrombus and venous bland thrombus in renal cell carcinoma

• Published in: Scientific reports 2022-01, Vol.12 (1), p.587-587, Article 587
• Main Authors: Zhu, An-hui, Hou, Xiao-yan, Tian, Shuai, Zhang, Wei-fang
• Format: Article
• Language: English
• Subjects: 631/67/2321; 631/67/589/1588; Blood clots; Humanities and Social Sciences; Kidney cancer; Magnetic resonance imaging; multidisciplinary; Occlusion; Positron emission tomography; Renal cell carcinoma; Science; Science (multidisciplinary); Thrombosis; Tumors
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-04541-9

The purpose of this study was to compare the ability of 18 F-FDG PET/CT and contrast-enhanced MRI (CEMRI) to detect and grade venous tumour thrombus (VTT) and venous bland thrombus (VBT) in RCC and assess invasion of the venous wall by VTT. The PET/CT and CEMRI data of 41 patients with RCC were retrieved. The difference in maximum standardized uptake value (SUVmax) between VTT and VBT was analysed. According to their pathological diagnosis, the patients were divided into those with and without venous wall invasion. The PET/CT and CEMRI features, including the SUVmax of the primary lesion and VTT, maximum venous diameter, complete occlusion of the vein by VTT, and VTT morphology, were compared between the two groups. All 41 patients had VTT, and eleven of the 41 patients had VBT. The mean SUVmax of the VTT (6.33 ± 4. 68, n = 41) was significantly higher than that of the VBT (1.37 ± 0.26, n = 11; P