A Review of Mitochondrial Optic Neuropathies: From Inherited to Acquired Forms

Abstract In recent years, the term mitochondrial optic neuropathy (MON) has increasingly been used within the literature to describe a group of optic neuropathies that exhibit mitochondrial dysfunction in retinal ganglion cells (RGCs). Interestingly, MONs include genetic aetiologies, such as Leber h...

Full description

Saved in:
Bibliographic Details
Published in:Journal of optometry 2017-10, Vol.10 (4), p.205-214
Main Authors: Pilz, Yasmine L, Bass, Sherry J, Sherman, Jerome
Format: Article
Language:English
Subjects:
células ganglionares de la retina
deficiencias nutricionales
Leber hereditary optic neuropathy
mitochondria
mitocondria
neuropatía óptica
Neuropatía Óptica Hereditaria de Leber
nutritional deficiencies
Ophthalmology
optic neuropathy
retinal ganglion cells
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract In recent years, the term mitochondrial optic neuropathy (MON) has increasingly been used within the literature to describe a group of optic neuropathies that exhibit mitochondrial dysfunction in retinal ganglion cells (RGCs). Interestingly, MONs include genetic aetiologies, such as Leber hereditary optic neuropathy (LHON) and dominant optic atrophy (DOA), as well as acquired aetiologies resulting from drugs, nutritional deficiencies, and mixed aetiologies. Regardless of an inherited or acquired cause, patients exhibit the same clinical manifestations with selective loss of the RGCs due to mitochondrial dysfunction. Various novel therapies are being explored to reverse or limit damage to the RGCs. Here we review the pathophysiology, clinical manifestations, differential diagnosis, current treatment, and promising therapeutic targets of MON.
ISSN:1888-4296
1989-1342
DOI:10.1016/j.optom.2016.09.003