Powdered Green Tea (Matcha) Attenuates the Cognitive Dysfunction via the Regulation of Systemic Inflammation in Chronic PM2.5-Exposed BALB/c Mice

This study was conducted to evaluate the anti-amnesic effect of the aqueous extract of powdered green tea (matcha) (EM) in particulate matter (PM)2.5-induced systemic inflammation in BALB/c mice. EM ameliorated spatial learning and memory function, short-term memory function, and long-term learning...

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Bibliographic Details
Published in:Antioxidants 2021-11, Vol.10 (12), p.1932
Main Authors: Kim, Jong Min, Kang, Jin Yong, Park, Seon Kyeong, Moon, Jong Hyun, Kim, Min Ji, Lee, Hyo Lim, Jeong, Hye Rin, Kim, Jong Cheol, Heo, Ho Jin
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Acids
Air pollution
Alzheimer's disease
Antioxidants
Apoptosis
Cholinergic transmission
Cognitive ability
Cytokines
Cytotoxicity
Gene expression
Green tea
Hippocampus
Inflammation
matcha
Membrane potential
Memory
Mitochondria
Olfactory bulb
Particulate matter
Physiology
PM2.5
powdered green tea
Reactive oxygen species
Short term memory
Spatial discrimination learning
Spatial memory
systemic inflammation
Tea
Tumor necrosis factor-TNF
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Summary:This study was conducted to evaluate the anti-amnesic effect of the aqueous extract of powdered green tea (matcha) (EM) in particulate matter (PM)2.5-induced systemic inflammation in BALB/c mice. EM ameliorated spatial learning and memory function, short-term memory function, and long-term learning and memory function in PM2.5-induced mice. EM protected against antioxidant deficit in pulmonary, dermal, and cerebral tissues. In addition, EM improved the cholinergic system through the regulation of acetylcholine (ACh) levels and acetylcholinesterase (AChE) activity in brain tissue, and it protected mitochondrial dysfunction by regulating the production of reactive oxygen species (ROS), mitochondrial membrane potential (MMP) and ATP contents in brain tissue. EM attenuated systemic inflammation and apoptotic signaling in pulmonary, dermal, olfactory bulb, and hippocampal tissues. Moreover, EM suppressed neuronal cytotoxicity and cholinergic dysfunction in hippocampal tissue. This study suggests that EM might be a potential substance to improve PM2.5-induced cognitive dysfunction via the regulation of systemic inflammation.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox10121932