Methotrexate Induced Pancytopenia

The well-reported methotrexate (MTX) toxicities are based on the duration and cumulative dosing of drug. The typical toxicities can be predicted by the timing of drug administration, where mucositis occurs as an earlier effect, while myelosuppression and the sequelae of pancytopenia occur later afte...

Full description

Saved in:
Bibliographic Details
Published in:Case reports in rheumatology 2014-01, Vol.2014 (2014), p.1-4
Main Authors: Gonzalez-Ibarra, Fernando, Eivaz-Mohammadi, Sahar, Surapaneni, Shiri, Alsaadi, Hazem, Syed, Amer K., Badin, Simon, Marian, Valentin, Elamir, Mazhar
Format: Article
Language:English
Subjects:
Case Report
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The well-reported methotrexate (MTX) toxicities are based on the duration and cumulative dosing of drug. The typical toxicities can be predicted by the timing of drug administration, where mucositis occurs as an earlier effect, while myelosuppression and the sequelae of pancytopenia occur later after MTX administration. Despite these well-known toxicities, low dose MTX therapy can become problematic, in particular with the elderly, who are at a greater risk for significant myelosuppression. We present a case of a 73-year-old female with pancytopenia causing severe neutropenia, mucocutaneous bleeding, and bruising and requiring intravenous antibiotic therapy and limited transfusion dependence as a result of low dose daily MTX for rheumatoid arthritis.
ISSN:2090-6889
2090-6897
DOI:10.1155/2014/679580