Prevalence of Unfavorable Video-Urodynamic Findings and Clinical Implications in Patients with Minimally Conscious State/Unresponsive Wakefulness Syndrome: A Retrospective Descriptive Analysis

The aim of this retrospective exploratory study was to investigate the prevalence of unfavorable findings during video-urodynamic studies (VUDS) in patients with minimally conscious state (MCS)/unresponsive wakefulness syndrome (UWS) and whether management of the lower urinary tract (LUT) was adjust...

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Bibliographic Details
Published in:Biomedicines 2023-08, Vol.11 (9), p.2432
Main Authors: Leboutte, Francois, Engesser, Christian, Zahiti, Leutrim, Rentsch, Cyrill A, Seifert, Helge, Anding, Ralf, Hund-Georgiadis, Margret, Möhr, Sandra, Walter, Matthias
Format: Article
Language:English
Subjects:
Bladder
bladder-emptying methods
Botulinum toxin
Catheters
Cognitive ability
Coma
Compliance
Consciousness
detrusor sphincter dyssynergia
indwelling catheters
Medical research
Medicine, Experimental
minimally conscious state
Mirabegron
neurogenic detrusor overactivity
neurogenic lower urinary tract dysfunction
Neurological disorders
Patients
Persistent vegetative state
Pharmaceuticals
Rehabilitation
Sleep and wakefulness
Sphincter
Traumatic brain injury
Urinary tract
Urinary tract infections
Urogenital system
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Summary:The aim of this retrospective exploratory study was to investigate the prevalence of unfavorable findings during video-urodynamic studies (VUDS) in patients with minimally conscious state (MCS)/unresponsive wakefulness syndrome (UWS) and whether management of the lower urinary tract (LUT) was adjusted accordingly. A retrospective chart review was conducted to screen for patients diagnosed with MCS/UWS at our rehabilitation center between 2011 and 2020. Patients 18 years or older were included and underwent baseline VUDS after being diagnosed with MCS/UWS. We analyzed urodynamic parameters and subsequent changes in LUT management in this cohort. In total, 32 patients (7 females, 25 males, median age 37 years) with MCS/UWS were included for analysis. While at least one unfavorable VUDS finding (i.e., neurogenic detrusor overactivity [NDO], detrusor sphincter dyssynergia {DSD, high maximum detrusor pressure during storage phase [>40 cmH O], low-compliance bladder [
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11092432