Intermediate Detection in the Casiopeina–Cysteine Interaction Ending in the Disulfide Bond Formation and Copper Reduction

A strategy to improve the cancer therapies involves agents that cause the depletion of the endogenous antioxidant glutathione (GSH), increasing its efflux out of cells and inducing apoptosis in tumoral cells due to the presence of reactive oxygen species. It has been shown that Casiopeina copper com...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-09, Vol.26 (19), p.5729
Main Authors: Ramírez-Palma, Lillian G., Espinoza-Guillén, Adrián, Nieto-Camacho, Fabiola, López-Guerra, Alexis E., Gómez-Vidales, Virginia, Cortés-Guzmán, Fernando, Ruiz-Azuara, Lena
Format: Article
Language:English
Subjects:
Antioxidants
Antitumor activity
Apoptosis
Cancer
Casiopeina
Copper
copper complexes
Copper compounds
copper reduction
Cysteine
Depletion
Disulfide bonds
Efflux
glutathione depletion
intermediate
Ligands
Oxidation
Oxidative stress
Reactive oxygen species
Spectrum analysis
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Summary:A strategy to improve the cancer therapies involves agents that cause the depletion of the endogenous antioxidant glutathione (GSH), increasing its efflux out of cells and inducing apoptosis in tumoral cells due to the presence of reactive oxygen species. It has been shown that Casiopeina copper complexes caused a dramatic intracellular GSH drop, forming disulfide bonds and reducing CuII to CuI. Herein, through the determination of the [CuII]–SH bond before reduction, we present evidence of the adduct between cysteine and one Casiopeina as an intermediate in the cystine formation and as a model to understand the anticancer activity of copper complexes. Evidence of such an intermediate has never been presented before.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26195729