Cross-sectional study of cholinergic urticaria subtypes and bronchial hyperresponsiveness

Cholinergic urticaria (CholU) is classified into several subtypes: (1) conventional sweat allergy-type CholU (conventional SAT-CholU), (2) CholU with palpebral angioedema (CholU-PA), 3) CholU with acquired anhidrosis and/or hypohidrosis (CholU-Anhd); 1) and 2) include SAT based on pathogenesis. Ther...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2022-10, Vol.12 (1), p.18122-18122, Article 18122
Main Authors: Katsurada, Naoko, Nagano, Tatsuya, Yamamoto, Masatsugu, Kiriu, Tatsunori, Dokuni, Ryota, Kamiryo, Hiroshi, Yoshioka, Ai, Fukunaga, Atsushi, Nishigori, Chikako, Nishimura, Yoshihiro, Kobayashi, Kazuyuki
Format: Article
Language:English
Subjects:
692/699/1785/31
692/699/4033
Allergies
Angioedema
Asthma
Asthma - diagnosis
Asthma - epidemiology
Bronchial Hyperreactivity
Cholinergic Agents
Cross-Sectional Studies
Humanities and Social Sciences
Humans
Methacholine
Methacholine Chloride
multidisciplinary
Nitric Oxide
Patients
Science
Science (multidisciplinary)
Urticaria
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cholinergic urticaria (CholU) is classified into several subtypes: (1) conventional sweat allergy-type CholU (conventional SAT-CholU), (2) CholU with palpebral angioedema (CholU-PA), 3) CholU with acquired anhidrosis and/or hypohidrosis (CholU-Anhd); 1) and 2) include SAT based on pathogenesis. There have been no studies on differences in the prevalence of bronchial asthma among the subtypes. We analyzed bronchial responsiveness using the methacholine dose indicator D min , respiratory symptoms, and exhaled nitric oxide (FeNO). Median log10 D min (interquartile range) of patients with conventional SAT-CholU (n = 11), CholU-PA (n = 11), and CholU-Anhd (n = 11) was 0.381 (− 0.829, 1.079), 0.717 (0.249, 0.787), and 1.318 (0.121, 1.699), respectively (p = 0.516). Respiratory symptoms were less frequently observed in CholU-Anhd than in conventional SAT-CholU or CholU-PA. FeNO of patients with conventional SAT-CholU, CholU-PA, and CholU-Anhd was 23 (18.5, 65.0), 39 (32.0, 59.5), and 25 (19.0, 33.0) ppb, respectively (p = 0.237). Nine% of conventional SAT-CholU patients and more than half of CholU-PA patients required treatment for asthma. Log D min tended to be lower in patients with SAT-CholU than in those with CholU-Anhd. CholU-PA might be associated with asthma.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-22655-6