Independent and interactive associations of heart rate and obesity with type 2 diabetes mellites: A population‐based study

• Published in: Journal of diabetes 2024-04, Vol.16 (4), p.e13529-n/a
• Main Authors: Zhu, Tianxin, Chen, Qingyu, Chen, Hongxing, You, Lili, Liu, Dan, Zhang, Xiaoyun, Li, Feng, Wu, Hongshi, Tang, Juying, Lin, Diaozhu, Sun, Kan, Yan, Li, Ren, Meng
• Format: Article
• Language: English
• Subjects: Diabetes; Glucose; Heart rate; interactive effects; Obesity; Original; Regression analysis; type 2 diabetes mellites
• ISSN: 1753-0393; 1753-0407
• DOI: 10.1111/1753-0407.13529

Background Although obesity and heart rate (HR) were closely related to the prevalence and development of type 2 diabetes mllitus (T2DM), few studies have shown a co‐association effect of them on T2DM. We aimed at assessing the interactive effects of HR and obesity with prevalence of T2DM in Chinese population, providing the exact cutpoint of the risk threshold for blood glucose with high HR. Materials and Methods In the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study (REACTION) cohorts (N = 8398), the relationship between HR and T2DM was explored by linear regression, logistic regression, and restricted cubic spline, and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Interaction terms between HR and body mass index (BMI) and HR and waist circumference (WC) were introduced into the logistic regression model. Results In those with HR > 88.0 beats/min, fasting plasma glucose and oral glucose tolerance tests were significantly correlated with HR, and the prevalence of T2DM was highly correlated with HR (all p