Synthesis and

Hybrids of bromopyrrole alkaloids with aroyl hydrazone feature were synthesized and evaluated for their anti-inflammatory activity using the carrageenan induced rat paw edema method. All the tested hybrids showed good anti-inflammatory activity with 64.78–86.03% inhibition of edema. Most active hybr...

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Bibliographic Details
Published in:Arabian journal of chemistry 2017-05, Vol.10 (4), p.458-464
Main Authors: Rajesh A. Rane, Mukesh Nandave, Suresh Nayak, Anushri Naik, Dhwani Shah, Wesam S. Alwan, Niteshkumar U. Sahu, Shital S. Naphade, Mahesh B. Palkar, Sivanandhan Karunanidhi, Neeta Thapliyal, Rajshekhar Karpoormath
Format: Article
Language:English
Subjects:
Anti-inflammatory activity
Anti-serotonergic 5-HT3
Antihistaminic H1
Aroyl hydrazones
Rat paw edema
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Summary:Hybrids of bromopyrrole alkaloids with aroyl hydrazone feature were synthesized and evaluated for their anti-inflammatory activity using the carrageenan induced rat paw edema method. All the tested hybrids showed good anti-inflammatory activity with 64.78–86.03% inhibition of edema. Most active hybrids 4b and 4f were further investigated for antihistaminic H1 [4b −8.09 μg/mL (18.5 μM); 4f −9.26 μg/mL (24.05 μM)] and anti-serotonergic 5-HT3 [4b −7.01 μg/mL (16.04 μM); 4f −9.64 μg/mL (25.04 μM)] activities. Molecule 4f with anti-inflammatory, anti-histaminic and anti-serotonergic activities emerges as a potential anti-inflammatory lead form in this study.
ISSN:1878-5352
DOI:10.1016/j.arabjc.2014.06.004