Impacts of impaired mitochondrial dynamics in hearing loss: Potential therapeutic targets

Mitochondria are the powerhouse of the cells. Under physiological conditions, mitochondrial fission and fusion maintain a dynamic equilibrium in the cytoplasm, which is referred to as mitochondrial dynamics. As an important approach to regulating mitochondrial function and quantity, the role of mito...

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Published in:Frontiers in neuroscience 2022-10, Vol.16, p.998507-998507
Main Authors: Zou, Tianyuan, Ye, Bin, Chen, Kaili, Zhang, Andi, Guo, Dongye, Pan, Yi, Ding, Rui, Hu, Haixia, Sun, Xingmei, Xiang, Mingliang
Format: Article
Language:English
Subjects:
Adenosine triphosphate
Age
Alzheimer's disease
Apoptosis
Auditory system
Brain injury
Cochlea
Cytochrome
Cytoplasm
Equilibrium
Hearing loss
Homeostasis
Mitochondria
Mitochondrial DNA
mitochondrial dynamics
mitochondrial quality control
Morphology
Mutation
Neurodegeneration
Neuroscience
OPA1
Pathogenesis
Peripheral neuropathy
Permeability
Phosphorylation
Proteins
Therapeutic targets
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Summary:Mitochondria are the powerhouse of the cells. Under physiological conditions, mitochondrial fission and fusion maintain a dynamic equilibrium in the cytoplasm, which is referred to as mitochondrial dynamics. As an important approach to regulating mitochondrial function and quantity, the role of mitochondrial dynamics has been demonstrated in the pathogenesis of various disease models, including brain damage, neurodegeneration, and stress. As the vital organ of the peripheral auditory system, the cochlea consumes a significant amount of energy, and the maintenance of mitochondrial homeostasis is essential for the cochlear auditory capacity. OPA1 functions as both a necessary gene regulating mitochondrial fusion and a pathogenic gene responsible for auditory neuropathy, suggesting that an imbalance in mitochondrial dynamics may play a critical role in hearing loss, but relevant studies are few. In this review, we summarize recent evidence regarding the role of mitochondrial dynamics in the pathogenesis of noise-induced hearing loss (NIHL), drug-induced hearing loss, hereditary hearing loss, and age-related hearing loss. The impacts of impaired mitochondrial dynamics on hearing loss are discussed, and the potential of mitochondrial dynamics for the prevention and treatment of hearing loss is considered.
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2022.998507