Association of elevated fractional exhaled nitric oxide concentration and blood eosinophil count with severe asthma exacerbations

Background Blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship of BEC and FeNO as complementary and independent biomarkers of severe asthma ex...

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Bibliographic Details
Published in:Clinical and translational allergy 2019-08, Vol.9 (1), p.41-n/a, Article 41
Main Authors: Price, David B., Bosnic‐Anticevich, Sinthia, Pavord, Ian D., Roche, Nicolas, Halpin, David M. G., Bjermer, Leif, Usmani, Omar S., Brusselle, Guy, Ming, Simon Wan Yau, Rastogi, Sarang
Format: Article
Language:English
Subjects:
Asthma
Biological markers
Biomarkers
Blood eosinophils
Clinical Medicine
Corticosteroid drugs
Eosinophils
Exhaled airway markers
Glucocorticoids
Health aspects
Klinisk medicin
Lungmedicin och allergi
Medical and Health Sciences
Medical research
Medicin och hälsovetenskap
Nitric oxide
Nitrogen oxides
Patient care
Patient outcomes
Respiratory Medicine and Allergy
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Summary:Background Blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship of BEC and FeNO as complementary and independent biomarkers of severe asthma exacerbations. Methods This observational study included data from the Optimum Patient Care Research Database. Asthma patients (18–80 years) with valid continuous data for 1 year before FeNO reading, ≥ 1 inhaled corticosteroid prescription, and BEC recorded ≤ 5 years before FeNO reading were separated into cohorts. Categorisation 1 was based on the American Thoracic Society criteria for elevated FeNO concentration (high: ≥ 50 ppb; non‐high: 
ISSN:2045-7022
2045-7022
DOI:10.1186/s13601-019-0282-7