The neutrophil/lymphocyte ratio as a predictor of successful conversion surgery for stage IV gastric cancer: a retrospective study

Conversion surgery (CS) following a response to chemotherapy occasionally leads to prolonged survival in patients with stage IV gastric cancer (GC). This study aimed to evaluate the predictive value of the neutrophil/lymphocyte ratio (NLR) for the success of CS in patients with stage IV GC. We retro...

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Bibliographic Details
Published in:BMC cancer 2020-04, Vol.20 (1), p.363-363, Article 363
Main Authors: Nakamura, Naohiko, Kinami, Shinichi, Tomita, Yasuto, Miyata, Takashi, Fujita, Hideto, Takamura, Hiroyuki, Ueda, Nobuhiko, Kosaka, Takeo
Format: Article
Language:English
Subjects:
Aged
Antigens
Biomarkers
Cancer
Cancer metastasis
Cancer research
Cancer therapies
Chemotherapy
Conversion surgery
Female
Follow-Up Studies
Gastrectomy
Gastric cancer
Humans
Lymphatic system
Lymphocytes
Lymphocytes - pathology
Male
Medical prognosis
Metastases
Metastasis
Multivariate analysis
Neoplasm Staging
Neutrophil/lymphocyte ratio
Neutrophils
Neutrophils - pathology
Patients
Peritoneum
Retrospective Studies
Stomach cancer
Stomach Neoplasms - blood
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Surgery
Survival analysis
Survival Rate
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Summary:Conversion surgery (CS) following a response to chemotherapy occasionally leads to prolonged survival in patients with stage IV gastric cancer (GC). This study aimed to evaluate the predictive value of the neutrophil/lymphocyte ratio (NLR) for the success of CS in patients with stage IV GC. We retrospectively analyzed data of 50 patients with stage IV GC who received systemic chemotherapy between January 2009 and December 2017 at the Kanazawa Medical University Hospital. The successful CS group included the patients who underwent R0 or R1 resection with CS, and the failed CS group included the patients who did not undergo CS after chemotherapy or those who, despite undergoing CS, had to additionally undergo R2 resection. Clinicopathological characteristics were examined in both groups. Univariate and multivariate analyses were performed to identify pretherapeutic parameters that were independently associated with the achievement of successful CS. The number of patients in the successful and failed CS groups were 12 and 38, respectively. On univariate analysis, gender (P = 0.01), NLR (P = 0.003), albumin levels (P = 0.004), and absence of peritoneal metastasis (P = 0.004) were found to be significantly correlated with a successful CS. On multivariate analysis, NLR 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-020-06884-4