Molecular Interactions between Dietary Lipids and Bone Tissue during Aging

Age-related bone disorders such as osteoporosis or osteoarthritis are a major public health problem due to the functional disability for millions of people worldwide. Furthermore, fractures are associated with a higher degree of morbidity and mortality in the long term, which generates greater finan...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-06, Vol.22 (12), p.6473
Main Authors: Romero-Márquez, Jose M., Varela-López, Alfonso, Navarro-Hortal, María D., Badillo-Carrasco, Alberto, Forbes-Hernández, Tamara Y., Giampieri, Francesca, Domínguez, Irma, Madrigal, Lorena, Battino, Maurizio, Quiles, José L.
Format: Article
Language:English
Subjects:
Age
Aging
Animals
Biomedical materials
Bone density
Bone diseases
Bone marrow
Bone turnover
Collagen
dietary lipids
Fatty acids
Fractures
Gene expression
Geriatrics
Growth factors
hallmarks of aging
Lipid metabolism
Lipids
Metabolism
Molecular interactions
Morbidity
Morphology
Musculoskeletal system
Osteoarthritis
Osteoporosis
Oxidative stress
Phosphatase
Proteins
Public health
Review
saturated fat diet
Stem cells
Transcription factors
Tumor necrosis factor-TNF
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Summary:Age-related bone disorders such as osteoporosis or osteoarthritis are a major public health problem due to the functional disability for millions of people worldwide. Furthermore, fractures are associated with a higher degree of morbidity and mortality in the long term, which generates greater financial and health costs. As the world population becomes older, the incidence of this type of disease increases and this effect seems notably greater in those countries that present a more westernized lifestyle. Thus, increased efforts are directed toward reducing risks that need to focus not only on the prevention of bone diseases, but also on the treatment of persons already afflicted. Evidence is accumulating that dietary lipids play an important role in bone health which results relevant to develop effective interventions for prevent bone diseases or alterations, especially in the elderly segment of the population. This review focuses on evidence about the effects of dietary lipids on bone health and describes possible mechanisms to explain how lipids act on bone metabolism during aging. Little work, however, has been accomplished in humans, so this is a challenge for future research.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22126473