Two Old Wild-Type Strains of Drosophila melanogaster Can Serve as an Animal Model of Faster and Slower Aging Processes

• Published in: Insects (Basel, Switzerland) Switzerland), 2024-05, Vol.15 (5), p.329
• Main Authors: Zakharenko, Lyudmila P, Bobrovskikh, Margarita A, Gruntenko, Nataly E, Petrovskii, Dmitrii V, Verevkin, Evgeniy G, Putilov, Arcady A
• Format: Article
• Language: English
• Subjects: Age; Aging; Animal models; Benzoates; Benzoic acid; Body weight; Caffeine; Carbohydrates; circadian rhythm; Cognition & reasoning; Comparative analysis; Darkness; Diet; Drosophila; Drosophila melanogaster; Environmental aspects; Environmental conditions; Environmental factors; Fecundity; Females; Food; Fruit flies; fruit fly; Genes; Genetic aspects; Genetics; Glucose; High carbohydrate diet; High temperature; Insects; Laboratories; Life expectancy; Life span; Locomotor activity; longevity; Low carbohydrate diet; Low temperature; Males; Metabolism; model organism; Physiological aspects; Physiological effects; Physiological responses; Physiology; Sleep; Sodium; Sugar
• ISSN: 2075-4450; 2075-4450
• DOI: 10.3390/insects15050329

provides a powerful platform to study the physiology and genetics of aging, i.e., the mechanisms underpinnings healthy aging, age-associated disorders, and acceleration of the aging process under adverse environmental conditions. Here, we tested the responses of daily rhythms to age-accelerated factors in two wild-type laboratory-adapted strains, Canton-S and Harwich. On the example of the 24 h patterns of locomotor activity and sleep, we documented the responses of these two strains to such factors as aging, high temperature, carbohydrate diet, and diet with different doses of caffeine-benzoate sodium. The strains demonstrated differential responses to these factors. Moreover, compared to Canton-S, Harwich showed a reduced locomotor activity, larger amount of sleep, faster rate of development, smaller body weight, lower concentrations of main sugars, lower fecundity, and shorter lifespan. It might be recommended to use at least two strains, one with a relatively fast and another with a relatively slow aging process, for the experimental elaboration of relationships between genes, environment, behavior, physiology, and health.