Biomimetic Mineralization of Magnetic Iron Oxide Nanoparticles Mediated by Bi-Functional Copolypeptides

Magnetite (Fe₃O₄) nanoparticles are widely used in multiple biomedical applications due to their magnetic properties depending on the size, shape and organization of the crystals. However, the crystal growth and morphology of Fe₃O₄ nanoparticles remain difficult to control without using organic solv...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-04, Vol.24 (7), p.1401
Main Authors: Liu, Liu, Pu, Ximing, Yin, Guangfu, Chen, Xianchun, Yin, Jie, Wu, Yuhao
Format: Article
Language:English
Subjects:
A2780 cell
Amino acids
Angiography
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Antioxidants
Biomedical materials
biomimetic mineralization
Biomimetics
Biosynthesis
Crystal growth
Crystals
Dietary minerals
Drug Delivery Systems
Fe3O4 nanoparticle
Female
Flavonoids
Ginger
High temperature
Humans
Iron oxides
Magnetic fields
Magnetic properties
Magnetite
Magnetite Nanoparticles - chemistry
Magnetite Nanoparticles - therapeutic use
Mineralization
Morphology
Nanoparticles
Ovarian cancer
Ovarian Neoplasms - drug therapy
Ovarian Neoplasms - metabolism
Ovarian Neoplasms - pathology
Peptides
Plant Extracts - chemistry
Plant Extracts - pharmacology
Proteins
targeting
Zingiber officinale - chemistry
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Summary:Magnetite (Fe₃O₄) nanoparticles are widely used in multiple biomedical applications due to their magnetic properties depending on the size, shape and organization of the crystals. However, the crystal growth and morphology of Fe₃O₄ nanoparticles remain difficult to control without using organic solvent or a high temperature. Inspired by the natural biomineralization process, a 14-mer bi-functional copolypeptide, leveraging the affinity of binding Fe₃O₄ together with targeting ovarian cancer cell A2780, was used as a template in the biomimetic mineralization of magnetite. Alongside this, a ginger extract was applied as an antioxidant and a size-conditioning agent of Fe₃O₄ crystals. As a result of the cooperative effects of the peptide and the ginger extract, the size and dispersibility of Fe₃O₄ were controlled based on the interaction of the amino acid and the ginger extract. Our study also demonstrated that the obtained particles with superparamagnetism could selectively be taken up by A2780 cells. In summary, the Fe₃O₄-QY-G nanoparticles may have potential applications in targeting tumor therapy or angiography.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24071401