A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

The timely and effective control and repair of wound bleeding is a key research issue all over the world. From traditional compression hemostasis to a variety of new hemostatic methods, people have a more comprehensive understanding of the hemostatic mechanism and the structure and function of diffe...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2022-06, Vol.12 (6), p.794
Main Authors: Ji, Yuexin, Song, Wenliang, Xu, Lin, Yu, Deng-Guang, Annie Bligh, Sim Wan
Format: Article
Language:English
Subjects:
Amino acids
Amino Acids - pharmacology
Angiogenesis
Bacteria
Biocompatibility
Blood platelets
Cell adhesion
Compression
electrospinning
Extracellular matrix
Fibroblasts
Foreign bodies
Hemostasis
Hemostatics - pharmacology
Humans
Infections
Medical dressings
Nanofibers - chemistry
Porosity
Review
Skin
Structure-function relationships
wound dressing
Wound Healing
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Summary:The timely and effective control and repair of wound bleeding is a key research issue all over the world. From traditional compression hemostasis to a variety of new hemostatic methods, people have a more comprehensive understanding of the hemostatic mechanism and the structure and function of different types of wound dressings. Electrospun nanofibers stand out with nano size, high specific surface area, higher porosity, and a variety of complex structures. They are high-quality materials that can effectively promote wound hemostasis and wound healing because they can imitate the structural characteristics of the skin extracellular matrix (ECM) and support cell adhesion and angiogenesis. At the same time, combined with amino acid polymers with good biocompatibility not only has high compatibility with the human body but can also be combined with a variety of drugs to further improve the effect of wound hemostatic dressing. This paper summarizes the application of different amino acid electrospun wound dressings, analyzes the characteristics of different materials in preparation and application, and looks forward to the development of directions of poly(amino acid) electrospun dressings in hemostasis.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom12060794