Prognostic and Clinicopathological Value of Ki-67 in Melanoma: A Meta-Analysis

The prognostic and clinicopathological value of Ki-67 in melanoma is controversial. The purpose of this meta-analysis was to determine the prognostic role of Ki-67 in melanoma patients. The PubMed, Cochrane Library, Web of Science, and Embase databases were searched systematically up to April 9, 202...

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Bibliographic Details
Published in:Frontiers in oncology 2021-09, Vol.11, p.737760-737760
Main Authors: Liu, Qixin, Peng, Ziheng, Shen, Liangfang, Shen, Lin
Format: Article
Language:English
Subjects:
clinicopathology
Ki-67
melanoma
meta-analysis
Oncology
prognosis
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Summary:The prognostic and clinicopathological value of Ki-67 in melanoma is controversial. The purpose of this meta-analysis was to determine the prognostic role of Ki-67 in melanoma patients. The PubMed, Cochrane Library, Web of Science, and Embase databases were searched systematically up to April 9, 2021. We calculated the pooled hazard ratios (HRs) and 95% confidence intervals (CIs) to determine the relationship between Ki-67 overexpression and survival outcomes. We also calculated the combined odds ratios (ORs) and 95% CIs to determine the relationship between Ki-67 expression levels and clinicopathologic parameters. All data were statistically analyzed by Stata 11.0. A total of 10 studies involving 929 patients were included in our meta-analysis. The pooled HR showed that Ki-67 overexpression was connected with poor overall survival rates (HR=2.92, 95% CI=2.17-3.91, p
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.737760