Wear of hip prostheses increases serum IGFBP-1 levels in patients with aseptic loosening

The biological mechanisms involved in aseptic loosening include inflammation-associated and bone resorption-associated processes. Coordinated cellular actions result in biochemical imbalances with devastating consequences for the joint. Given that this condition is not known for showing systemic sig...

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Bibliographic Details
Published in:Scientific reports 2021-01, Vol.11 (1), p.576-576, Article 576
Main Authors: Vallés, Gema, García-Rey, Eduardo, Saldaña, Laura, García-Cimbrelo, Eduardo, Vilaboa, Nuria
Format: Article
Language:English
Subjects:
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Bone implants
Bone resorption
Enzyme-linked immunosorbent assay
Hip
Humanities and Social Sciences
Inflammation
Insulin
Insulin-like growth factor-binding protein 1
Joint surgery
Macrophages
multidisciplinary
Osteoblasts
Osteolysis
Prosthetics
Science
Science (multidisciplinary)
Serum levels
Surgery
Titanium
Total hip arthroplasty
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Summary:The biological mechanisms involved in aseptic loosening include inflammation-associated and bone resorption-associated processes. Coordinated cellular actions result in biochemical imbalances with devastating consequences for the joint. Given that this condition is not known for showing systemic signs, we investigated whether circulating levels of inflammation-related proteins are altered in patients with aseptic loosening. Our study included 37 patients who underwent revision surgery due to hip osteolysis and aseptic loosening and 31 patients who underwent primary total hip arthroplasty. Using antibody arrays, we evaluated the serum levels of 320 proteins in four patients from each group. The results showed differences in insulin-like growth factor-binding protein 1 (IGFBP-1) concentrations, which we then quantified using enzyme-linked immunosorbent assay tests in all study patients. The results confirmed that serum IGFBP-1 concentrations were higher in the revision surgery patients than in the hip arthroplasty patients. In vitro studies showed that exposure of human osteoblasts to titanium particles induced an IGFBP-1 release that further increased when exposure to particles was performed in media conditioned by human M1 macrophages. These findings suggest that elevated serum IGFBP-1 levels in patients with aseptic loosening can arise from increased local IGFBP-1 production in the inflammatory environment of the periprosthetic bed.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-79813-x