Insights on Juniperus phoenicea Essential Oil as Potential Anti-Proliferative, Anti-Tyrosinase, and Antioxidant Candidate

In this study, the anti-cancer, anti-tyrosinase, and antioxidant activities of essential oils (EOs) of berries and leaves of Juniperus phoenicea grown wild in North of Tunisia were investigated. The EO yields from leaves and berries were 1.69% and 0.45%, respectively. GC-MS analysis revealed that α-...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-11, Vol.28 (22), p.7547
Main Authors: Mansour, Rim Ben, Wasli, Hanen, Bourgou, Soumaya, Khamessi, Saber, Ksouri, Riadh, Megdiche-Ksouri, Wided, Cardoso, Susana M.
Format: Article
Language:English
Subjects:
anti-tyrosinase
anticancer
Antioxidants
Berries
Cancer therapies
Cytotoxicity
essential oil
GC-MS
Juniperus phoenicea
Kinases
Natural products
North Tunisia
Oils & fats
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Summary:In this study, the anti-cancer, anti-tyrosinase, and antioxidant activities of essential oils (EOs) of berries and leaves of Juniperus phoenicea grown wild in North of Tunisia were investigated. The EO yields from leaves and berries were 1.69% and 0.45%, respectively. GC-MS analysis revealed that α-pinene is the predominant component in both EOs (44.17 and 83.56%, respectively). Leaves essential oil presented high levels of β-phellandrene (18%) and camphene (15%). The EOs displayed cytotoxic effects against MCF-7 breast cancer cell, HT-29 colon cancer, and the normal cells H9C2 cardiomyoblasts. Leaves oil strongly inhibited colon cell line proliferation (IC50 of 38 µg/mL), while berries essential oil was more potent against breast cancerous cells MCF-7 (IC50 of 60 µg/mL). Interestingly, berries essential oil exhibited high ability to inhibit melanin synthesis by inhibiting enzyme mono and diphenolase activities. Overall, the results suggested that the two oils are significant sources of healthy natural chemicals.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28227547