Determinants and clinical outcomes of stroke following revascularization among patients with reduced ejection fraction

Objective Stoke after revascularization including both percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) is an uncommon but devastating complication. Patients with reduced ejection fraction (EF) had an increased risk of stroke after revascularization. However, littl...

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Bibliographic Details
Published in:Brain and behavior 2023-04, Vol.13 (4), p.e2927-n/a
Main Authors: Wang, Shaoping, Ran, Yuhua, Cheng, Shujuan, Lyu, Yi, Liu, Jinghua
Format: Article
Language:English
Subjects:
Angioplasty
Cardiovascular disease
Clinical outcomes
Cohort Studies
Coronary Artery Disease
Coronary vessels
Diabetes
Ejection fraction
Heart attacks
heart failure
Heart surgery
Hospitals
Humans
Hypertension
Medical imaging
Medical records
Original
Patients
Percutaneous Coronary Intervention - adverse effects
Regression analysis
revascularization
Stents
Stroke
Stroke - epidemiology
Stroke - etiology
Stroke Volume
Treatment Outcome
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Summary:Objective Stoke after revascularization including both percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) is an uncommon but devastating complication. Patients with reduced ejection fraction (EF) had an increased risk of stroke after revascularization. However, little is known about the determinants and outcomes of stroke among patients with reduced EF following revascularization. Materials and Methods A cohort study of patients with preoperative reduced EF (≤40%) who received revascularization by either PCI or CABG between January 1, 2005 and December 31, 2014 was performed. Multivariate logistic regression was used to identify independent correlates of stroke. Logistic regression models were applied to evaluate the association of stroke with clinical outcomes. Results A total of 1937 patients were enrolled in this study. Of these, 111 (5.7%) patients suffered from stroke during the median 3.5‐year follow‐up. Older age (odds ratio [OR], 1.03; 95% CI, 1.01–1.05; p = .009), history of hypertension (OR, 1.79; 95% CI, 1.18–2.73; p = .007), and history of stroke (OR, 2.00; 95% CI, 1.19–3.36; p = .008) were found to be independent predictors for stroke. Patients with and without stroke had similar risk of all‐cause death (OR, 0.91; 95% CI, 0.59–1.41; p = .670). However, stroke was associated with higher odds ratio of heart failure (HF) hospitalization (OR, 2.77; 95% CI, 1.74–4.40; p 
ISSN:2162-3279
2162-3279
DOI:10.1002/brb3.2927