WD Repeat and HMG Box DNA Binding Protein 1: An Oncoprotein at the Hub of Tumorigenesis and a Novel Therapeutic Target

WD repeat and HMG-box DNA binding protein 1 (WDHD1) is a highly conserved gene from yeast to humans. It actively participates in DNA replication, playing a crucial role in DNA damage repair and the cell cycle, contributing to centromere formation and sister chromosome segregation. Notably, several s...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-08, Vol.24 (15), p.12494
Main Authors: Zhang, Zhiwei, Zhu, Qing
Format: Article
Language:English
Subjects:
Amino acids
Breast cancer
Cancer
Carcinogenesis - genetics
Carcinoma
Cell cycle
Cell division
Cell Transformation, Neoplastic
Chromosomes
Cyclin-dependent kinases
Development and progression
DNA
DNA damage
DNA polymerase
DNA replication
Drug resistance
Esophageal cancer
Genes
Genomes
Health aspects
Humans
Kinases
Lung Neoplasms
Oncogene Proteins
Phylogenetics
proliferation
Protein binding
Proteins
Review
tumorigenesis
Tumors
WD repeat and HMG-box DNA binding protein 1
WD40 Repeats
Yeast
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Summary:WD repeat and HMG-box DNA binding protein 1 (WDHD1) is a highly conserved gene from yeast to humans. It actively participates in DNA replication, playing a crucial role in DNA damage repair and the cell cycle, contributing to centromere formation and sister chromosome segregation. Notably, several studies have implicated WDHD1 in the development and progression of diverse tumor types, including esophageal carcinoma, pulmonary carcinoma, and breast carcinoma. Additionally, the inhibitor of WDHD1 has been found to enhance radiation sensitivity, improve drug resistance, and significantly decrease tumor cell proliferation. This comprehensive review aims to provide an overview of the molecular structure, biological functions, and regulatory mechanisms of WDHD1 in tumors, thereby establishing a foundation for future investigations and potential clinical applications of WDHD1.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241512494