Hyperlipidemia in immune thrombocytopenia: a retrospective study

Background Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by low platelet count and bleeding manifestations. However, some patients also suffered from atherosclerosis or even infarction. Apart from activated platelets, lipid metabolism takes a large part in the form...

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Published in:Thrombosis journal 2023-10, Vol.21 (1), p.1-102, Article 102
Main Authors: Han, Shouqing, Lu, Hui, Yu, Yafei, Liu, Xinguang, Jing, Fangmiao, Wang, Liang, Zhao, Yajing, Hou, Ming
Format: Article
Language:English
Subjects:
Age
Atherosclerosis
Autoimmune diseases
Bleeding
Blood lipids
Blood platelets
Body mass index
Care and treatment
Cholesterol
Hematology
High density lipoprotein
Hospitals
Hyperlipidemia
Hypertension
Immune thrombocytopenia
Lipid metabolism
Lipids
Metabolic disorders
Metabolic syndrome
Physiological aspects
Regression analysis
Software
Statins
Statistical analysis
Steroids
Thrombocytopenia
Thrombosis
Type 2 diabetes
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container_end_page 102
container_issue 1
container_start_page 1
container_title Thrombosis journal
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creator Han, Shouqing
Lu, Hui
Yu, Yafei
Liu, Xinguang
Jing, Fangmiao
Wang, Liang
Zhao, Yajing
Hou, Ming
description Background Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by low platelet count and bleeding manifestations. However, some patients also suffered from atherosclerosis or even infarction. Apart from activated platelets, lipid metabolism takes a large part in the formation of atherosclerosis and metabolic syndrome. The lipid metabolic state in ITP patients is still unknown. Methods We retrospectively reviewed 302 hospitalized ITP patients in our cohort, comparing their blood lipids, bleeding symptoms, metabolic diseases and treatment responses. Results We found a high proportion of ITP patients suffered from hyperlipidemia, and other metabolic diseases including cardiovascular or cerebral atherosclerosis or infarction, hypertension, and type 2 diabetes. Hyperlipidemia was associated with severe bleeding and treatment refractoriness in ITP. Statins could alleviate thrombocytopenia and bleeding severity, and facilitate ITP treatment, while improving hyperlipidemia in ITP patients. Conclusions Our present study demonstrated that lipid metabolism might play an indispensable role in ITP pathogenesis and development. Keywords: Immune thrombocytopenia, Bleeding, Lipid metabolism, Statins
doi_str_mv 10.1186/s12959-023-00545-9
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However, some patients also suffered from atherosclerosis or even infarction. Apart from activated platelets, lipid metabolism takes a large part in the formation of atherosclerosis and metabolic syndrome. The lipid metabolic state in ITP patients is still unknown. Methods We retrospectively reviewed 302 hospitalized ITP patients in our cohort, comparing their blood lipids, bleeding symptoms, metabolic diseases and treatment responses. Results We found a high proportion of ITP patients suffered from hyperlipidemia, and other metabolic diseases including cardiovascular or cerebral atherosclerosis or infarction, hypertension, and type 2 diabetes. Hyperlipidemia was associated with severe bleeding and treatment refractoriness in ITP. Statins could alleviate thrombocytopenia and bleeding severity, and facilitate ITP treatment, while improving hyperlipidemia in ITP patients. Conclusions Our present study demonstrated that lipid metabolism might play an indispensable role in ITP pathogenesis and development. Keywords: Immune thrombocytopenia, Bleeding, Lipid metabolism, Statins</description><identifier>ISSN: 1477-9560</identifier><identifier>EISSN: 1477-9560</identifier><identifier>DOI: 10.1186/s12959-023-00545-9</identifier><language>eng</language><publisher>London: BioMed Central Ltd</publisher><subject>Age ; Atherosclerosis ; Autoimmune diseases ; Bleeding ; Blood lipids ; Blood platelets ; Body mass index ; Care and treatment ; Cholesterol ; Hematology ; High density lipoprotein ; Hospitals ; Hyperlipidemia ; Hypertension ; Immune thrombocytopenia ; Lipid metabolism ; Lipids ; Metabolic disorders ; Metabolic syndrome ; Physiological aspects ; Regression analysis ; Software ; Statins ; Statistical analysis ; Steroids ; Thrombocytopenia ; Thrombosis ; Type 2 diabetes</subject><ispartof>Thrombosis journal, 2023-10, Vol.21 (1), p.1-102, Article 102</ispartof><rights>COPYRIGHT 2023 BioMed Central Ltd.</rights><rights>2023. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>BioMed Central Ltd., part of Springer Nature 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-72f9f6c6d8bb2af2b90fda84f20cc365ee3f2ac61f7162ac757168cec9663f163</citedby><cites>FETCH-LOGICAL-c541t-72f9f6c6d8bb2af2b90fda84f20cc365ee3f2ac61f7162ac757168cec9663f163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544441/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2877504694?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25751,27922,27923,37010,37011,38514,43893,44588,53789,53791</link.rule.ids></links><search><creatorcontrib>Han, Shouqing</creatorcontrib><creatorcontrib>Lu, Hui</creatorcontrib><creatorcontrib>Yu, Yafei</creatorcontrib><creatorcontrib>Liu, Xinguang</creatorcontrib><creatorcontrib>Jing, Fangmiao</creatorcontrib><creatorcontrib>Wang, Liang</creatorcontrib><creatorcontrib>Zhao, Yajing</creatorcontrib><creatorcontrib>Hou, Ming</creatorcontrib><title>Hyperlipidemia in immune thrombocytopenia: a retrospective study</title><title>Thrombosis journal</title><description>Background Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by low platelet count and bleeding manifestations. However, some patients also suffered from atherosclerosis or even infarction. Apart from activated platelets, lipid metabolism takes a large part in the formation of atherosclerosis and metabolic syndrome. The lipid metabolic state in ITP patients is still unknown. Methods We retrospectively reviewed 302 hospitalized ITP patients in our cohort, comparing their blood lipids, bleeding symptoms, metabolic diseases and treatment responses. Results We found a high proportion of ITP patients suffered from hyperlipidemia, and other metabolic diseases including cardiovascular or cerebral atherosclerosis or infarction, hypertension, and type 2 diabetes. Hyperlipidemia was associated with severe bleeding and treatment refractoriness in ITP. Statins could alleviate thrombocytopenia and bleeding severity, and facilitate ITP treatment, while improving hyperlipidemia in ITP patients. Conclusions Our present study demonstrated that lipid metabolism might play an indispensable role in ITP pathogenesis and development. 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However, some patients also suffered from atherosclerosis or even infarction. Apart from activated platelets, lipid metabolism takes a large part in the formation of atherosclerosis and metabolic syndrome. The lipid metabolic state in ITP patients is still unknown. Methods We retrospectively reviewed 302 hospitalized ITP patients in our cohort, comparing their blood lipids, bleeding symptoms, metabolic diseases and treatment responses. Results We found a high proportion of ITP patients suffered from hyperlipidemia, and other metabolic diseases including cardiovascular or cerebral atherosclerosis or infarction, hypertension, and type 2 diabetes. Hyperlipidemia was associated with severe bleeding and treatment refractoriness in ITP. Statins could alleviate thrombocytopenia and bleeding severity, and facilitate ITP treatment, while improving hyperlipidemia in ITP patients. Conclusions Our present study demonstrated that lipid metabolism might play an indispensable role in ITP pathogenesis and development. Keywords: Immune thrombocytopenia, Bleeding, Lipid metabolism, Statins</abstract><cop>London</cop><pub>BioMed Central Ltd</pub><doi>10.1186/s12959-023-00545-9</doi><oa>free_for_read</oa></addata></record>
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subjects Age
Atherosclerosis
Autoimmune diseases
Bleeding
Blood lipids
Blood platelets
Body mass index
Care and treatment
Cholesterol
Hematology
High density lipoprotein
Hospitals
Hyperlipidemia
Hypertension
Immune thrombocytopenia
Lipid metabolism
Lipids
Metabolic disorders
Metabolic syndrome
Physiological aspects
Regression analysis
Software
Statins
Statistical analysis
Steroids
Thrombocytopenia
Thrombosis
Type 2 diabetes
title Hyperlipidemia in immune thrombocytopenia: a retrospective study
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