Electro-polymerization of modified carbon paste sensor for detecting azithromycin

Azithromycin (AM) is one of the prescribed drugs in pandemic medication treatment which has paid great attention. We developed in this study a simply modified carbon paste electrode (CPE) to detect AM using poly-threonine (PT). PT or similar polymers are used as carriers to enhance the delivery and...

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Bibliographic Details
Published in:Scientific reports 2025-01, Vol.15 (1), p.980-11, Article 980
Main Authors: Mamdouh, Salma, Shehata, M., Fekry, A. M., Ameer, M. A.
Format: Article
Language:English
Subjects:
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704/172
Anti-Bacterial Agents - analysis
Antibiotics
Antiviral
Azithromycin
Azithromycin - analysis
Carbon
Carbon - chemistry
COVID-19
Dielectric Spectroscopy - methods
Electro-polymerization
Electrochemical Techniques - methods
Electrochemistry
Electrodes
Humanities and Social Sciences
Humans
Hydrogen-Ion Concentration
L-Threonine
Limit of Detection
Microscopy, Electron, Scanning
multidisciplinary
pH effects
Polymerization
Polymers
Polymers - chemistry
Scanning electron microscopy
Science
Science (multidisciplinary)
Spectroscopy
Threonine
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Summary:Azithromycin (AM) is one of the prescribed drugs in pandemic medication treatment which has paid great attention. We developed in this study a simply modified carbon paste electrode (CPE) to detect AM using poly-threonine (PT). PT or similar polymers are used as carriers to enhance the delivery and effectiveness of AM. The work was characterised via Cyclic Voltammetry (CV), electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM). We take into consideration the effects of pH, scan rate, accumulation time, interference, and calibration curve.A very sensitive response to the oxidation of 1.0 mM from AM in phosphate buffer solution (PBS) over a pH range of 5.0 to 10.0 was observed using the developed poly-threonine carbon paste electrode (PTCPE). The impact of different AM concentrations was investigated resulting in a detection limit of 0.32 µM and a quantification limit of 1.07 µM at PBS (pH 7.4). Finally, the recently used electrode realized acceptable sensitivity and consistency for AM detection in pharmaceutical drugs.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-79614-6