Development of a Flow Injection System for Differential Pulse Amperometry and Its Application for Diazepam Determination

This work presents the development of a flow injection system for differential pulse amperometry (DPA) for diazepam determination in the presence of oxygen. The thin flow cell consisted of the bare glassy carbon electrode, reference silver/silver chloride, and stainless steel as the auxiliary electr...

Full description

Saved in:
Bibliographic Details
Published in:Journal of analytical methods in chemistry 2018-01, Vol.2018 (2018), p.1-6
Main Authors: Antunovic, Vesna, Tesanovic, Slavna, Peruskovic, Danica, Stevanovic, Nikola, Baosic, Rada, Mandic, Snezana, Lolic, Aleksandar
Format: Article
Language:English
Subjects:
Beverages
Chemical reduction
Detectors
Diazepam
Electrical measurement
Electrodes
Glassy carbon
Ions
Oxazepam
Oxidation
Pharmaceuticals
Schiff bases
Sensors
Silver chloride
Steel, Stainless
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This work presents the development of a flow injection system for differential pulse amperometry (DPA) for diazepam determination in the presence of oxygen. The thin flow cell consisted of the bare glassy carbon electrode, reference silver/silver chloride, and stainless steel as the auxiliary electrode. Electrochemical reduction of diazepam (DZP) was characterised by cyclic voltammetry. Azomethine reduction peak was used for DZP quantification. The detector response was linear in the range 20–250 µmol/dm3 of diazepam, with a calculated detection limit of 3.83 µg/cm3. Intraday and interday precision were 1.53 and 10.8%, respectively. The method was applied on three beverage samples, energetic drink, and two different beer samples, and obtained recoveries were from 93.65 up to 104.96%. The throughoutput of the method was up to 90 analyses per hour.
ISSN:2090-8865
2090-8873
DOI:10.1155/2018/6121489