Microbiota profiles in the saliva, cancerous tissues and its companion paracancerous tissues among Chinese patients with lung cancer

Despite the growing interest in the impact of the gut microbiome on cancer, the relationship between the lung microbiome and lung cancer has received limited investigation. Additionally, the composition of the oral microbiome was found to differ from that of individuals with lung cancer, indicating...

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Bibliographic Details
Published in:BMC microbiology 2023-08, Vol.23 (1), p.237-8, Article 237
Main Authors: Zhou, Yuhan, Zeng, Hongfen, Liu, Kai, Pan, Hui, Wang, Baohui, Zhu, Minghua, Wang, Jiawei, Wang, Haoyi, Chen, Hongwei, Shen, Dan, Wang, Yue, Yu, Zhaonan
Format: Article
Language:English
Subjects:
Analysis
Antibiotics
Bioinformatics
Biological markers
Biomarkers
Cancer
Cancer patients
Cancer therapies
Cancerous tissue
Chemotherapy
Composition
Development and progression
Diagnosis
East Asian People
Health aspects
Humans
Immunotherapy
Intestinal microflora
Lung cancer
Lung diseases
Lung Neoplasms
Methods
Microbiology
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Microbiota - genetics
Microenvironments
Microorganisms
Mouth
Oncology, Experimental
Paracancerous tissue
Pathogenesis
Patients
Physical therapy
Physiological aspects
Relative abundance
Retrospective Studies
RNA
rRNA
Saliva
Salivary diagnostics
Species diversity
Species richness
Surgery
Taxonomy
Therapeutic targets
Tumor Microenvironment
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Summary:Despite the growing interest in the impact of the gut microbiome on cancer, the relationship between the lung microbiome and lung cancer has received limited investigation. Additionally, the composition of the oral microbiome was found to differ from that of individuals with lung cancer, indicating that these microorganisms may serve as potential biomarkers for the detection of lung cancer. Forty-three Chinese lung cancer patients were enrolled in the current retrospective study and 16 S rRNA sequencing was performed on saliva, cancerous tissue (CT) and paracancerous tissue (PT) samples. Diversity and species richness were significantly different between the oral and lung microbiota. Lung microbiota were largely composed of the phyla Proteobacteria, Firmicutes, Bacteroidetes and Actinobacteria. The relative abundance of Promicromonosporacea and Chloroflexi increased in CT, while Enterococcaceae and Enterococcus were enriched in PT (p
ISSN:1471-2180
1471-2180
DOI:10.1186/s12866-023-02882-1