Antiapoptotic and anticoagulant effects of camel milk and camel urine in methotrexate-induced hepatotoxicity

Methotrexate (MTX) is widely used chemotherapeutic and immune suppressant agent. Hepatotoxicity is a common side effect of chronic MTX therapy. This study investigated the hepatoprotective properties of camel milk (CM) and camel urine (CU) in hepatotoxicity induced by intraperitoneal injection of MT...

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Bibliographic Details
Published in:CYTA: journal of food 2023-12, Vol.21 (1), p.357-365
Main Authors: Al-Ghumlas, Abeer Khalid, Alhakbany, Manan A., Korish, Aida A.
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
Albumin
Albumins
Alkaline phosphatase
anticoagulant
Anticoagulants
Antioxidants
Antithrombin
Apoptosis
Aspartate aminotransferase
camel milk
camel urine
Camel's milk
Camelids
Chronic illnesses
CK-18
Creatinine
Cytokeratin
DNA fragmentation
Drinking water
Enzymes
Fibrinogen
Hepatotoxicity
Laboratory animals
Liver
Medicine
Methotrexate
Physiology
Proteins
Prothrombin
Rodents
Serum proteins
Thromboplastin
Toxicity
Transaminases
Urine
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Summary:Methotrexate (MTX) is widely used chemotherapeutic and immune suppressant agent. Hepatotoxicity is a common side effect of chronic MTX therapy. This study investigated the hepatoprotective properties of camel milk (CM) and camel urine (CU) in hepatotoxicity induced by intraperitoneal injection of MTX 20 mg/kg. The MTX-intoxicated animals showed elevated serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, fasting blood glucose (FBG), liver DNA fragmentation marker (DFF-40), and serum and liver cytokeratin (CK-18), decreased serum proteins, albumin, fibrinogen, and total antioxidant capacity (TAC). Decreased antithrombin (AT) was associated with prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT). Treatment with CM and CU for four weeks decreased the liver enzymes, FBG, DFF-40, and CK-18 levels and increased total proteins, albumin, fibrinogen, and TAC. However, the changes in AT, PT, and APTT persisted. CM and CU showed promising abilities to counteract MTX hepatotoxicity and they exerted cytoprotective, antiapoptotic, antioxidative, antihyperglycemic, and antithrombotic effects.
ISSN:1947-6337
1947-6345
DOI:10.1080/19476337.2023.2202709