Predictors of Major Bleeding and Mortality in Dengue Infection: A Retrospective Observational Study in a Tertiary Care Centre in South India

We conducted a retrospective observational study to describe the clinical profile and outcomes of patients admitted with a diagnosis of dengue fever in a tertiary hospital in South India. A total of 159 patients admitted from April 2014 to October 2018 were included in the study. Vomiting (70.4%), m...

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Bibliographic Details
Published in:Interdisciplinary perspectives on infectious diseases 2019, Vol.2019 (2019), p.1-7
Main Authors: Iyyadurai, Ramya, Sultan, N., Das, Sohini, Mathew, Divya, Prasad, John Davis, Gunasekaran, Karthik, John, Kevin, Abraham, Asha Mary
Format: Article
Language:English
Subjects:
Clinical Study
Dengue fever
Mortality
Observational studies
Systematic review
Tropical diseases
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Summary:We conducted a retrospective observational study to describe the clinical profile and outcomes of patients admitted with a diagnosis of dengue fever in a tertiary hospital in South India. A total of 159 patients admitted from April 2014 to October 2018 were included in the study. Vomiting (70.4%), myalgia (60.4%), headache (42.1%), abdominal pain (38.4%), bleeding (38%), and rash (37.1%) were the most common symptoms at presentation. The mean duration of hospital stay was 4.9 days (SD ± 2.4), and the median cost was INR 19,708 ($285) (IQR INR 12,968–32,056 ($188–$305)). Major bleeding was associated with elevated SGOT and SGPT, severe dengue, and secondary dengue. Mortality was associated with elderly age; elevated total leukocyte count, serum bilirubin, serum creatinine, SGOT, and SGPT; and high SOFA score. In view of these observations, we recommend stratifying patients according to the WHO classification of dengue and avoiding the use of thrombocytopenia as a single marker of the severity of the illness.
ISSN:1687-708X
1687-7098
DOI:10.1155/2019/4823791