The role of the Xpert MTB/RIF assay among adolescents suspected of pulmonary tuberculosis in Rio de Janeiro, Brazil

The teste rápido molecular para tuberculose (TRM-TB) was introduced in 2014 in Brazil for tuberculosis screening. However, its role in adolescents in Brazil has not been studied. A descriptive study of adolescents with suspected tuberculosis using National Laboratory software. Of 852 (15.4%) suspect...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 2018-03, Vol.51 (2), p.234-236
Main Authors: Sieiro, Thania Luiza de Andrade, Aurílio, Rafaela Baroni, Soares, Elizabeth Cristina C, Chiang, Silvia S, Sant Anna, Clemax Couto
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Antibiotics, Antitubercular - pharmacology
Child
Cross-Sectional Studies
Drug resistance
Genotype
Humans
Isoniazid - pharmacology
Microbial Sensitivity Tests
Molecular chains
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Polymerase chain reaction
Rifampin
Rifampin - pharmacology
Streptomycin - pharmacology
Teenagers
TROPICAL MEDICINE
Tuberculosis
Tuberculosis, Multidrug-Resistant - diagnosis
Tuberculosis, Multidrug-Resistant - drug therapy
Tuberculosis, Multidrug-Resistant - microbiology
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Summary:The teste rápido molecular para tuberculose (TRM-TB) was introduced in 2014 in Brazil for tuberculosis screening. However, its role in adolescents in Brazil has not been studied. A descriptive study of adolescents with suspected tuberculosis using National Laboratory software. Of 852 (15.4%) suspected cases, 131 were positive by TRM-TB and 2% were resistant to rifampicin. Among TRM-TB-positive cases, 105 (91.4%) were culture-positive. Sixty-four of 96 samples were sensitive to rifampicin by TRM-TB; 11 were resistant to other drugs by drug sensitivity test (DST). Among suspected cases, 16% were diagnosed by TRM-TB, of which 17% were drug-resistant by DST.
ISSN:0037-8682
1678-9849
1678-9849
DOI:10.1590/0037-8682-0298-2017