Immunostimulant Effect of Egyptian Propolis in Rabbits

The present experiment was conducted to study the effect of ethanolic extract of Egyptian propolis given alone or in combination with inactivated Pasteurella multocida vaccine on rabbits challenged with a virulent strain of Pasteurella multocida. Fifty-six New-Zealand rabbits, 6–8 weeks old and non-...

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Bibliographic Details
Published in:TheScientificWorld 2012-01, Vol.2012 (2012), p.1-9
Main Authors: Nassar, Somya A., Mohamed, Amira H., Soufy, Hamdy, Nasr, Soad M., Mahran, K. M.
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - therapeutic use
Animals
Apis mellifera
Body weight
Care and treatment
Health aspects
Immune response
Immune system
Immunostimulants
Male
Materia medica, Vegetable
Organs
Pasteurella
Pasteurella infections
Pasteurella Infections - immunology
Pasteurella Infections - prevention & control
Pasteurella multocida
Pasteurella multocida - immunology
Pasteurella multocida - pathogenicity
Pasteurellosis
Plant extracts
Propolis
Propolis - therapeutic use
Rabbits
Vaccines
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Summary:The present experiment was conducted to study the effect of ethanolic extract of Egyptian propolis given alone or in combination with inactivated Pasteurella multocida vaccine on rabbits challenged with a virulent strain of Pasteurella multocida. Fifty-six New-Zealand rabbits, 6–8 weeks old and non-vaccinated against pasteurellosis, were randomly divided into eight equal groups. The first group was kept as a control for the experiment. The other groups received different treatments with propolis extract, inactivated vaccine, or both. The experiment continued for seven weeks during which clinical signs, body weight, and mortality rate were monitored, and blood samples were collected weekly for evaluating the leukogram, serum biochemistry, and immune response in all groups of animals. At the end of the seventh week, the animals were subjected to challenge with a virulent strain of Pasteurella multocida. Two weeks later, tissue specimens were collected from different organs for histopathological examination. Results showed that rabbits of the groups treated with both propolis and the vaccine by different routes appeared healthy after challenge. It has been concluded that alcoholic extract of propolis administrated in combination with inactivated Pasteurella multocida vaccine has no adverse effects on the general health conditions and enhances immune response in rabbits.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1100/2012/901516