Interleukin-7 Biology and Its Effects on Immune Cells: Mediator of Generation, Differentiation, Survival, and Homeostasis

Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B cells, remains one of the most extensively studied cytokines. It plays a vital role in health maintenance and disease prevention, and the congenital deficiency of IL-7 signaling leads to profound immunodefici...

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Bibliographic Details
Published in:Frontiers in immunology 2021-12, Vol.12, p.747324-747324
Main Authors: Chen, Deng, Tang, Ting-Xuan, Deng, Hai, Yang, Xiang-Ping, Tang, Zhao-Hui
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation - immunology
Cell Survival - immunology
differentiation
generation
homeostasis
Homeostasis - immunology
Humans
IL-7
immune cells
Immune System - cytology
Immune System - immunology
Immunology
Interleukin-7 - immunology
survival
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Summary:Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B cells, remains one of the most extensively studied cytokines. It plays a vital role in health maintenance and disease prevention, and the congenital deficiency of IL-7 signaling leads to profound immunodeficiency. IL-7 contributes to host defense by regulating the development and homeostasis of immune cells, including T lymphocytes, B lymphocytes, and natural killer (NK) cells. Clinical trials of recombinant IL-7 have demonstrated safety and potent immune reconstitution effects. In this article, we discuss IL-7 and its functions in immune cell development, drawing on a substantial body of knowledge regarding the biology of IL-7. We aim to answer some remaining questions about IL-7, providing insights essential for designing new strategies of immune intervention.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.747324